K
Kenneth Simon
Researcher at Biogen Idec
Publications - 31
Citations - 2561
Kenneth Simon is an academic researcher from Biogen Idec. The author has contributed to research in topics: JC virus & Progressive multifocal leukoencephalopathy. The author has an hindex of 20, co-authored 31 publications receiving 2421 citations. Previous affiliations of Kenneth Simon include Cold Spring Harbor Laboratory & Stony Brook University.
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Journal ArticleDOI
Anti-JC virus antibodies: implications for PML risk stratification.
Leonid Gorelik,Michaela Lerner,Sarah A. Bixler,Mary Crossman,Brian Schlain,Kenneth Simon,Amy Pace,Anne Cheung,Ling Ling Chen,Melissa Berman,Fairuz Zein,Ewa Wilson,Ted Yednock,Alfred Sandrock,Susan Goelz,Meena Subramanyam +15 more
TL;DR: A study was undertaken to establish an enzyme‐linked immunosorbent assay (ELISA) to detect JC virus (JCV)‐specific antibodies in multiple sclerosis patients, and to evaluate its potential utility for identifying patients at higher or lower risk of developing progressive multifocal leukoencephalopathy (PML).
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Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation
Gerald S. Horan,Susan Wood,Victor Ona,Dan Jun Li,Matvey E. Lukashev,Paul H. Weinreb,Kenneth Simon,Kyungmin Hahm,Norm Allaire,Nicola J. Rinaldi,Jaya Goyal,Carol Feghali-Bostwick,Eric L. Matteson,Carl O'Hara,Robert Lafyatis,Gerald S. Davis,Xiaozhu Huang,Dean Sheppard,Shelia M. Violette +18 more
TL;DR: αvβ6 is overexpressed in human lung fibrosis within pneumocytes lining the alveolar ducts and alveol...
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Identification and Characterization of Mefloquine Efficacy against JC Virus In Vitro
Margot Brickelmaier,Alexey Lugovskoy,Ramya Kartikeyan,Marta M. Reviriego-Mendoza,Norm Allaire,Kenneth Simon,Richard J. Frisque,Leonid Gorelik +7 more
TL;DR: In vitro results suggest that mefloquine could be an effective therapy for PML, and quantitative PCR to quantify the number of viral copies in cultured cells shows that me floquine inhibits viral DNA replication.
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αvβ6 Integrin Regulates Renal Fibrosis and Inflammation in Alport Mouse
Kyungmin Hahm,Matvey E. Lukashev,Yi Luo,William Yang,Brian M. Dolinski,Paul H. Weinreb,Kenneth Simon,Li Chun Wang,Diane R Leone,Roy R. Lobb,Donald J. McCrann,Norm Allaire,Gerald S. Horan,Agnes B. Fogo,Raghu Kalluri,Raghu Kalluri,Raghu Kalluri,Charles F. Shield,Dean Sheppard,Humphrey Gardner,Shelia M. Violette +20 more
TL;DR: It is demonstrated that αvβ6 can contribute to the regulation of renal fibrosis and suggest this integrin as a potential therapeutic target.
Journal ArticleDOI
Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design
Louis A. Clark,P. Ann Boriack-Sjodin,John Eldredge,Christopher Fitch,Bethany Friedman,Karl J. M. Hanf,Matthew Jarpe,Stefano F. Liparoto,You Li,Alexey Lugovskoy,Miller Stephan S,Mia Rushe,Woody Sherman,Kenneth Simon,Herman W. T. van Vlijmen +14 more
TL;DR: The results indicate that structure‐based computational design can be successfully applied to further improve the binding of high‐affinity antibodies and improve the single‐mutant success rate.