D
Deqiang Jing
Researcher at Cornell University
Publications - 34
Citations - 5642
Deqiang Jing is an academic researcher from Cornell University. The author has contributed to research in topics: Brain-derived neurotrophic factor & Tropomyosin receptor kinase B. The author has an hindex of 23, co-authored 31 publications receiving 4881 citations. Previous affiliations of Deqiang Jing include Vanderbilt University Medical Center.
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Journal ArticleDOI
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
Zhe-Yu Chen,Deqiang Jing,Kevin G. Bath,Alessandro Ieraci,Tanvir Khan,Chia-Jen Siao,Daniel G. Herrera,Miklós Tóth,Chingwen Yang,Bruce S. McEwen,Barbara L. Hempstead,Francis S. Lee +11 more
TL;DR: A variant BDNF mouse (BDNFMet/Met) is generated that reproduces the phenotypic hallmarks in humans with the variant allele and may play a key role in genetic predispositions to anxiety and depressive disorders.
Journal ArticleDOI
A Genetic Variant BDNF Polymorphism Alters Extinction Learning in Both Mouse and Human
Fatima Soliman,Charles E. Glatt,Kevin G. Bath,Liat Levita,Rebecca M. Jones,Siobhan S. Pattwell,Deqiang Jing,Nim Tottenham,Dima Amso,Leah H. Somerville,Henning U. Voss,Gary H. Glover,Douglas Ballon,Conor Liston,Theresa Teslovich,Tracey A. Van Kempen,Francis S. Lee,B. J. Casey +17 more
TL;DR: Parallel phenotypes in mice and humans resulting from a common single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene, which is involved in anxiety-related behavior are identified.
Journal ArticleDOI
Neuronal release of proBDNF
Jianmin Yang,Chia-Jen Siao,Guhan Nagappan,Tina Marinic,Deqiang Jing,Kelly McGrath,Zhe-Yu Chen,Willie Mark,Lino Tessarollo,Francis S. Lee,Bai Lu,Barbara L. Hempstead +11 more
TL;DR: Using new tools to quantitate endogenous BDNF isoforms, it is found that mouse neurons secrete both proBDNF and mature BDNF, and BDNF actions are developmentally regulated by secretion ofPro–brain-derived neurotrophic factor or mature BD NF and by local expression of p75 and TrkB.
Journal ArticleDOI
Altered fear learning across development in both mouse and human.
Siobhan S. Pattwell,Stéphanie Duhoux,Catherine A. Hartley,David C. Johnson,Deqiang Jing,Mark D. Elliott,Erika J. Ruberry,Alisa Powers,Natasha Mehta,Rui R. Yang,Fatima Soliman,Charles E. Glatt,B. J. Casey,Ipe Ninan,Francis S. Lee +14 more
TL;DR: The results suggest a lack of synaptic plasticity in the prefrontal regions, during adolescence, is associated with blunted regulation of fear extinction, which provides insight into optimizing treatment outcomes for when, during development, exposure therapies may be most effective.
Journal ArticleDOI
Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice
Sergey V. Shmelkov,Adilia Hormigo,Adilia Hormigo,Adilia Hormigo,Deqiang Jing,Catia C. Proenca,Catia C. Proenca,Kevin G. Bath,Till Milde,Evgeny Shmelkov,Jared S Kushner,Muhamed Baljevic,Iva Dincheva,Andrew J. Murphy,David M. Valenzuela,Nicholas W. Gale,George D. Yancopoulos,Ipe Ninan,Francis S. Lee,Shahin Rafii +19 more
TL;DR: It is demonstrated that loss of a neuron-specific transmembrane protein, SLIT and NTRK-like protein-5 (Slitrk5), leads to OCD- like behaviors in mice, which manifests as excessive self-grooming and increased anxiety-like behaviors, and is alleviated by the selective serotonin reuptake inhibitor fluoxetine.