Showing papers by "Derek Bell published in 2002"
TL;DR: Insulin aspart in CSII was as efficacious and well tolerated as BR and lispro and is a suitable insulin for continuous subcutaneous insulin infusion using external pumps.
Abstract: OBJECTIVE —To compare the safety and efficacy of insulin aspart (IAsp), buffered regular insulin (BR), and insulin lispro administered by continuous subcutaneous insulin infusion (CSII) in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS —After completing a 4-week run-in period with BR, 146 adult patients with type 1 diabetes (with pretrial CSII experience) were randomly assigned (2:2:1) to CSII treatment with IAsp, BR, or lispro for 16 weeks in a multicenter, open-label, randomized, parallel-group study. Bolus insulin doses were administered 30 min before meals (BR) or immediately before meals (IAsp or lispro). RESULTS —Treatment groups had similar baseline HbA 1c (7.3% ±0.7 for IAsp, 7.5% ±0.8 for BR, and 7.3% ±0.7 for lispro). After 16 weeks of treatment, HbA 1c values were relatively unchanged from baseline, and the mean changes in baseline HbA 1c values were not significantly different between the three groups (0.00 ±0.51, 0.15 ±0.63, and 0.18 ±0.84 for the IAsp, BR, and lispro groups, respectively). The rates of hypoglycemic episodes (blood glucose CONCLUSIONS —Insulin aspart in CSII was as efficacious and well tolerated as BR and lispro and is a suitable insulin for continuous subcutaneous insulin infusion using external pumps.
145 citations
TL;DR: It is often assumed that neutralist liberalism and environmentalism are incompatible because promoting environmentally friendly policies involves endorsing a particular conception of the good life as discussed by the authors, which is not the case.
Abstract: It is often assumed that neutralist liberalism and environmentalism are incompatible because promoting environmentally friendly policies involves endorsing a particular conception of the good life....
65 citations
TL;DR: In this article, the authors examine four aspects of these criticisms - lack of a coherent vision, low public profile, failure as a regulator, and lack of accountability, and conclude that until and unless the Government takes steps to clarify precisely what is the Environment Agency's proper role, the critics have often failed to take into account the constraints under which the Agency operates.
Abstract: In the six years of its existence, the Environment Agency for England and Wales has acquired a key role in improving Britain's environment. But a recent report from the House of Commons Select Committee has severely criticised its performance. In this article, we examine four aspects of these criticisms - lack of a coherent vision, low public profile, failure as a regulator, and lack of accountability. Our conclusion is that the critics have often failed to take into account the constraints under which the Agency operates, and that until and unless the Government takes steps to clarify precisely what is the Agency's proper role - whether, for example, as champion of the environment or a champion of sustainable development.
24 citations
15 citations
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