Institution
Eastern Maine Medical Center
Healthcare•Bangor, Maine, United States•
About: Eastern Maine Medical Center is a healthcare organization based out in Bangor, Maine, United States. It is known for research contribution in the topics: Population & Hazard ratio. The organization has 302 authors who have published 393 publications receiving 17937 citations. The organization is also known as: Eastern Maine.
Papers published on a yearly basis
Papers
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Harvard University1, Imperial College London2, University of Paris3, University of Missouri–Kansas City4, Mayo Clinic5, Duke University6, University of Vermont7, Case Western Reserve University8, Lenox Hill Hospital9, Stanford University10, Great Lakes Institute of Management11, Eastern Maine Medical Center12, Carolinas Healthcare System13, Boston University14
TL;DR: Dual antiplatelet therapy beyond 1 year after placement of a drug-eluting stent, as compared with aspirin therapy alone, significantly reduced the risks of stent thrombosis and major adverse cardiovascular and cerebrovascular events but was associated with an increased risk of bleeding.
Abstract: 0.29 [95% confidence interval {CI}, 0.17 to 0.48]; P<0.001) and major adverse cardiovascular and cerebrovascular events (4.3% vs. 5.9%; hazard ratio, 0.71 [95% CI, 0.59 to 0.85]; P<0.001). The rate of myocardial infarction was lower with thienopyridine treatment than with placebo (2.1% vs. 4.1%; hazard ratio, 0.47; P<0.001). The rate of death from any cause was 2.0% in the group that continued thienopyridine therapy and 1.5% in the placebo group (hazard ratio, 1.36 [95% CI, 1.00 to 1.85]; P = 0.05). The rate of moderate or severe bleeding was increased with continued thienopyridine treatment (2.5% vs. 1.6%, P = 0.001). An elevated risk of stent thrombosis and myocardial infarction was observed in both groups during the 3 months after discontinuation of thienopyridine treatment. Conclusions Dual antiplatelet therapy beyond 1 year after placement of a drug-eluting stent, as compared with aspirin therapy alone, significantly reduced the risks of stent thrombosis and major adverse cardiovascular and cerebrovascular events but was associated with an increased risk of bleeding. (Funded by a consortium of eight device and drug manufacturers and others; DAPT ClinicalTrials.gov number, NCT00977938.)
1,587 citations
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TL;DR: Angiography is inaccurate in assessing the functional significance of a coronary stenosis when compared with the FFR, not only in the 50% to 70% category but also in the 70% to 90% angiographic severity category.
1,019 citations
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TL;DR: Routine measurement of FFR in patients with multivessel CAD undergoing PCI with drug-eluting stents significantly reduces mortality and myocardial infarction at 2 years when compared with standard angiography-guided PCI.
946 citations
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TL;DR: In this paper, the authors present a decision-making in regard to elective repair of abdominal aortic aneurysms (AAA) requires careful assessment of factors that influence rupture risk, operative mortality, and life expectancy.
769 citations
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Baylor College of Medicine1, University of Illinois at Chicago2, University of Texas Health Science Center at San Antonio3, St. Joseph's Hospital and Medical Center4, University of Rochester5, University of California, San Francisco6, Washington University in St. Louis7, Eastern Maine Medical Center8, University of Michigan9, University of Connecticut10, Boston Children's Hospital11, Oklahoma State University–Stillwater12, University of Toronto13, University of Arkansas for Medical Sciences14
TL;DR: It is proposed that recurrent reciprocal microdeletions and microduplications within 1q21.1 represent previously unknown genomic disorders characterized by abnormal head size along with a spectrum of developmental delay, neuropsychiatric abnormalities, dysmorphic features and congenital anomalies.
Abstract: Chromosome region 1q21.1 contains extensive and complex low-copy repeats, and copy number variants (CNVs) in this region have recently been reported in association with congenital heart defects, developmental delay, schizophrenia and related psychoses. We describe 21 probands with the 1q21.1 microdeletion and 15 probands with the 1q21.1 microduplication. These CNVs were inherited in most of the cases in which parental studies were available. Consistent and statistically significant features of microcephaly and macrocephaly were found in individuals with microdeletion and microduplication, respectively. Notably, a paralog of the HYDIN gene located on 16q22.2 and implicated in autosomal recessive hydrocephalus was inserted into the 1q21.1 region during the evolution of Homo sapiens; we found this locus to be deleted or duplicated in the individuals we studied, making it a probable candidate for the head size abnormalities observed. We propose that recurrent reciprocal microdeletions and microduplications within 1q21.1 represent previously unknown genomic disorders characterized by abnormal head size along with a spectrum of developmental delay, neuropsychiatric abnormalities, dysmorphic features and congenital anomalies. These phenotypes are subject to incomplete penetrance and variable expressivity.
562 citations
Authors
Showing all 305 results
Name | H-index | Papers | Citations |
---|---|---|---|
Atul K. Bhan | 95 | 331 | 33636 |
Stacey E. Mills | 71 | 264 | 15279 |
Andrew Sherwood | 60 | 229 | 16625 |
Amanda Henderson | 37 | 200 | 4447 |
Felix Hernandez | 28 | 38 | 4024 |
Robert A. Clough | 27 | 45 | 4220 |
Tobias A. Mattei | 22 | 153 | 1265 |
Michael Rocque | 21 | 87 | 1807 |
John D. Klemperer | 20 | 30 | 2172 |
Basem M. William | 20 | 118 | 1477 |
Marie J. Hayes | 19 | 43 | 1356 |
Joseph V. Sakran | 18 | 101 | 1142 |
Burton H. Harris | 17 | 45 | 1080 |
W. Andrew Hodge | 17 | 26 | 1854 |
Mark S. Brown | 15 | 21 | 958 |