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Derek J. Royer
Researcher at University of Oklahoma Health Sciences Center
Publications - 18
Citations - 376
Derek J. Royer is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 10, co-authored 17 publications receiving 317 citations. Previous affiliations of Derek J. Royer include University of Oklahoma.
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Journal ArticleDOI
Microglia and a Functional Type I IFN Pathway Are Required To Counter HSV-1–Driven Brain Lateral Ventricle Enlargement and Encephalitis
Christopher D. Conrady,Min Zheng,Nico van Rooijen,Douglas A. Drevets,Derek J. Royer,Anthony M. Alleman,Daniel J.J. Carr +6 more
TL;DR: Using magnetic resonance imaging and type I IFN receptor–deficient mouse chimeras, it is demonstrated HSV-1 gains access to the murine brain stem and subsequently brain ependymal cells, leading to enlargement of the cerebral lateral ventricle and infection of the brain parenchyma in mice.
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Granulocytes in Ocular HSV-1 Infection: Opposing Roles of Mast Cells and Neutrophils.
TL;DR: Findings provide new insight into host defense in the cornea and the pathogenesis of HSV-1 infection by identifying previously unacknowledged MCs as protective innate sentinels for infection of the ocular surface and reinforcing that neutrophils are detrimental to corneal infection.
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Thrombocytopenia as an adverse effect of complementary and alternative medicines, herbal remedies, nutritional supplements, foods, and beverages
TL;DR: The association of thrombocytopenia with complementary/alternative medicines, herbal remedies, nutritional supplements, foods, and beverages has been rarely described, except for reports of thROMbocy topenia caused by quinine‐containing beverages.
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A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin
Derek J. Royer,Daniel J.J. Carr +1 more
TL;DR: The presence of STING was critical for sustained control of HSV-1 replication in the corneal epithelium and resistance to viral neuroinvasion, but loss of STing had a negligible impact with respect to gross tissue pathology.
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A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral Immunity
Derek J. Royer,Hem R. Gurung,Jeremy K. Jinkins,Joshua Geltz,Jennifer Lee Wu,William P. Halford,Daniel J.J. Carr +6 more
TL;DR: Overall, 0ΔNLS affords remarkable protection against HSV-1-associated ocular sequelae by impeding viral replication, dissemination, and establishment of latency, which underscores the necessity to reconsider strategies that utilize attenuated live virus as opposed to subunit vaccines against ocular HSV -1 infection.