A STING-dependent innate-sensing pathway mediates resistance to corneal HSV-1 infection via upregulation of the antiviral effector tetherin
Derek J. Royer,Daniel J.J. Carr +1 more
Reads0
Chats0
TLDR
The presence of STING was critical for sustained control of HSV-1 replication in the corneal epithelium and resistance to viral neuroinvasion, but loss of STing had a negligible impact with respect to gross tissue pathology.About:
This article is published in Mucosal Immunology.The article was published on 2016-07-01 and is currently open access. It has received 33 citations till now. The article focuses on the topics: Sting & Tetherin.read more
Citations
More filters
Journal ArticleDOI
Neuro-Immune Interactions at Barrier Surfaces
TL;DR: This Review focuses on neuro-immune interactions at barrier surfaces-mostly the gut, but also including the skin and the airways, areas densely populated by neurons and immune cells that constantly sense and adapt to tissue-specific environmental challenges.
Journal ArticleDOI
TMEM173 variants and potential importance to human biology and disease
Seema Patel,Lei Jin +1 more
TL;DR: The human TMEM173 gene encodes the protein STING, a key player in host defense against pathogens, a promising therapeutic target for cancers and infectious diseases and their potential impact on human health and medicine is reviewed.
Journal ArticleDOI
Accumulation of Cytoplasmic DNA Due to ATM Deficiency Activates the Microglial Viral Response System with Neurotoxic Consequences.
Xuan Song,Fulin Ma,Karl Herrup +2 more
TL;DR: It is shown here that the innateimmune system is not spared in A-T and the microglia of the innate immune system are also affected and the mechanism by which this occurs is uncovered.
Journal ArticleDOI
Herpes Simplex Virus 1 γ 1 34.5 Protein Inhibits STING Activation That Restricts Viral Replication
TL;DR: HSV-1 γ134.5 targets stimulator of interferon genes (STING) in the intracellular DNA recognition pathway that regulates TBK1 activation and disrupts translocation of STING, a process necessary to prime cellular immunity.
Book ChapterDOI
Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease.
TL;DR: The major host innate immune mechanisms and the HSV evasion mechanisms that have evolved are summarized and how disease can result if this equilibrium between virus and host response is disrupted is discussed.
References
More filters
Journal ArticleDOI
Monocyte and macrophage heterogeneity
Siamon Gordon,Philip R. Taylor +1 more
TL;DR: Recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues.
Journal ArticleDOI
Monocyte recruitment during infection and inflammation
Chao Shi,Eric G. Pamer +1 more
TL;DR: The mechanisms that control monocyte trafficking under homeostatic, infectious and inflammatory conditions are being unravelled and are the focus of this Review.
Journal ArticleDOI
Regulation of type I interferon responses
TL;DR: In this paper, the authors summarize the signalling and epigenetic mechanisms that regulate type I IFN-induced STAT activation and ISG transcription and translation and conclude that these regulatory mechanisms determine the biological outcomes of type I ILN responses and whether pathogens are cleared effectively or chronic infection or autoimmune disease ensues.
Journal ArticleDOI
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
TL;DR: It is shown that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species produced by various DNA pathogens after infection.
Journal ArticleDOI
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures.
TL;DR: Applied aspects that arise from an increase in knowledge in this area are described, including vaccine design and manufacture, the development of novel antiviral drugs and the use of IFN-sensitive oncolytic viruses in the treatment of cancer.
Related Papers (5)
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Herpes Simplex Epithelial and Stromal Keratitis: An Epidemiologic Update
Asim V. Farooq,Deepak Shukla +1 more