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Derek S. Tan
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 102
Citations - 4254
Derek S. Tan is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Glycal & Total synthesis. The author has an hindex of 35, co-authored 97 publications receiving 3771 citations. Previous affiliations of Derek S. Tan include Cornell University & Columbia University.
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Diversity-oriented synthesis: exploring the intersections between chemistry and biology
TL;DR: Diversity-oriented synthesis has provided powerful probes to investigate biological mechanisms and also served as a new driving force for advancing synthetic organic chemistry.
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Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis
TL;DR: The design, synthesis and biological evaluation of a mechanism-based inhibitor of domain salicylation enzymes required for siderophore biosynthesis in M. tuberculosis and Y. pestis are reported, which could provide a valuable new line of defense against intractable multiple-drug-resistant infections.
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Stereoselective Synthesis of over Two Million Compounds Having Structural Features Both Reminiscent of Natural Products and Compatible with Miniaturized Cell-Based Assays
TL;DR: The synthetic strategy undertaken is to develop highly efficient multistep syntheses of natural product-like compounds that include several coupling steps and to use split-pool techniques at these steps in order to generate diverse outcomes.
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Active site remodelling accompanies thioester bond formation in the SUMO E1
TL;DR: Crystal structures for human SUMO E1 in complex with SUMO adenylate and tetrahedral intermediate analogues show that side chain contacts to ATP·Mg are released after adnylation to facilitate a 130 degree rotation of the Cys domain during thioester bond formation that is accompanied by remodelling of key structural elements.
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Synthesis and Preliminary Evaluation of a Library of Polycyclic Small Molecules for Use in Chemical Genetic Assays
TL;DR: After development of several efficient coupling reactions of iodobenzyl tetracycles 12b−d and completion of extensive validation protocols, a split-pool synthesis yielded a binary encoded library calculated to contain 2.18 million polycyclic compounds.