The past decade has highlighted the central role of epigenetic processes in cancer causation, progression and treatment. Next-generation sequencing is providing a window for visualizing the human epigenome and how it is altered in cancer. This view provides many surprises, including linking epigenetic abnormalities to mutations in genes that control DNA methylation, the packaging and the function of DNA in chromatin, and metabolism. Epigenetic alterations are leading candidates for the development of specific markers for cancer detection, diagnosis and prognosis. The enzymatic processes that control the epigenome present new opportunities for deriving therapeutic strategies designed to reverse transcriptional abnormalities that are inherent to the cancer epigenome.

http://sdjohnston.faculty.noctrl.edu/360/Cancer%20Epigenome.pdf

A decade of exploring the cancer epigenome — biological and translational implications

http://www.uniroma2.it/didattica/Genomica_BTI/deposito/Mamm_Epigenome_rev_Cell.pdf

The mammalian epigenome.

http://basicmed.med.ncku.edu.tw/admin/up_img/970513-3.pdf

A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

New methods for the genome-wide analysis of chromatin are providing insight into its roles in development and their underlying mechanisms. Current studies indicate that chromatin is dynamic, with its structure and its histone modifications undergoing global changes during transitions in development and in response to extracellular cues. In addition to DNA methylation and histone modification, ATP-dependent enzymes that remodel chromatin are important controllers of chromatin structure and assembly, and are major contributors to the dynamic nature of chromatin. Evidence is emerging that these chromatin-remodelling enzymes have instructive and programmatic roles during development. Particularly intriguing are the findings that specialized assemblies of ATP-dependent remodellers are essential for establishing and maintaining pluripotent and multipotent states in cells.

/pdf/chromatin-remodelling-during-development-2wwvqnja7q.pdf

Chromatin remodelling during development

https://www.cell.com/developmental-cell/pdf/S1534-5807(05)00421-1.pdf

Dhananjay Yellajoshula

Papers

Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells