Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells
Eran Meshorer,Dhananjay Yellajoshula,Eric M. George,Peter J. Scambler,David T. Brown,Tom Misteli +5 more
TLDR
It is suggested that hyperdynamic binding of structural chromatin proteins is a functionally important hallmark of pluripotent ES cells that contributes to the maintenance of plasticity in undifferentiated ES cells and to establishing higher-order chromatin structure.About:
This article is published in Developmental Cell.The article was published on 2006-01-01 and is currently open access. It has received 1003 citations till now. The article focuses on the topics: Chromatin binding & Chromatin.read more
Citations
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A decade of exploring the cancer epigenome — biological and translational implications
Stephen B. Baylin,Peter A. Jones +1 more
TL;DR: Next-generation sequencing is providing a window for visualizing the human epigenome and how it is altered in cancer, including linking epigenetic abnormalities to mutations in genes that control DNA methylation, the packaging and the function of DNA in chromatin, and metabolism.
Journal ArticleDOI
The mammalian epigenome.
TL;DR: Current research efforts are reviewed, with an emphasis on large-scale studies, emerging technologies, and challenges ahead.
Journal ArticleDOI
A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells
TL;DR: The results of a genome-wide analysis of human cells suggest that most protein-coding genes, including most genes thought to be transcriptionally inactive, experience transcription initiation, and that transcription initiation at most genes is a general phenomenon in human cells.
Journal ArticleDOI
Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Aaron D Goldberg,Laura A. Banaszynski,Kyung-Min Noh,Peter W. Lewis,Simon J. Elsaesser,Sonja C. Stadler,Scott Dewell,Martin J. Law,Xingyi Guo,Xuan Li,Duancheng Wen,Duancheng Wen,Ariane Chapgier,Russell Dekelver,Jeffrey C. Miller,Ya Li Lee,Elizabeth A. Boydston,Michael C. Holmes,Philip D. Gregory,John M. Greally,Shahin Rafii,Shahin Rafii,Chingwen Yang,Peter J. Scambler,David Garrick,Richard J. Gibbons,Douglas R. Higgs,Ileana M. Cristea,Fyodor D. Urnov,Deyou Zheng,C. David Allis +30 more
TL;DR: It is demonstrated that multiple and distinct factors are responsible for H3.3 localization at specific genomic locations in mammalian cells.
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Chromatin remodelling during development
Lena Ho,Gerald R. Crabtree +1 more
TL;DR: New methods for the genome-wide analysis of chromatin are providing insight into its roles in development and their underlying mechanisms, and particularly intriguing are the findings that specialized assemblies of ATP-dependent remodellers are essential for establishing and maintaining pluripotent and multipotent states in cells.
References
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Rudolf Jaenisch,Adrian Bird +1 more
TL;DR: Advances in the understanding of the mechanism and role of DNA methylation in biological processes are reviewed, showing that epigenetic mechanisms seem to allow an organism to respond to the environment through changes in gene expression.
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Megabase chromatin domains involved in DNA double-strand breaks in vivo.
TL;DR: The results offer direct visual confirmation that γ-H2AX forms en masse at chromosomal sites of DNA double-strand breaks and suggest the possible existence of units of higher order chromatin structure involved in monitoring DNA integrity.
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Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
Sang-Hun Lee,Nadya Lumelsky,Lorenz Studer,Lorenz Studer,Jonathan M. Auerbach,Ronald D.G. McKay +5 more
TL;DR: A method for obtaining dopaminergic (DA) and serotonergic neurons in high yield from mouse ES cells in vitro is presented and it is demonstrated that the ES cells can be obtained in unlimited numbers and that these neuron types are generated efficiently.
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Histone H3.1 and H3.3 Complexes Mediate Nucleosome Assembly Pathways Dependent or Independent of DNA Synthesis
TL;DR: Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for the DNA-synthesis-independent deposition pathway, and purified deposition machineries for these histones are presented.
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Epigenetic reprogramming in mouse primordial germ cells.
Petra Hajkova,Sylvia Erhardt,Natasha Lane,Thomas Haaf,Osman El-Maarri,Wolf Reik,Jörn Walter,M. Azim Surani +7 more
TL;DR: It is shown that mouse primordial germ cells (PGCs) exhibit dynamic changes in epigenetic modifications between days 10.5 and 12.5 post coitum (dpc), and it is suggested that this is an active demethylation process initiated upon the entry of PGCs into the gonadal anlagen.
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