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Dharma R. Thapa
Researcher at University of California, Los Angeles
Publications - 12
Citations - 911
Dharma R. Thapa is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Transactivation & Beta defensin. The author has an hindex of 11, co-authored 12 publications receiving 869 citations. Previous affiliations of Dharma R. Thapa include Biogen Idec.
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Journal ArticleDOI
Differential regulation of beta-defensin expression in human skin by microbial stimuli.
TL;DR: During inflammation, epidermal expression of β-defensins is mediated by at least three different mechanisms, which are distinct from each other and from the IL-1-dependent induction of hBD-2 expression.
Journal ArticleDOI
Urinary hepcidin in congenital chronic anemias.
Susan Kearney,Elizabeta Nemeth,Ellis J. Neufeld,Dharma R. Thapa,Tomas Ganz,David A. Weinstein,David A. Weinstein,Melody J. Cunningham,Melody J. Cunningham +8 more
TL;DR: Patients with congenital chronic anemias have high levels of hepcidin, a regulator for iron homeostasis, which is induced by inflammation and iron burden and suppressed by anemia and hypoxia.
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Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor
Ole E. Sørensen,Dharma R. Thapa,K. Markus Roupé,Erika V. Valore,Ulf Sjöbring,Alice A. Roberts,Artur Schmidtchen,Tomas Ganz +7 more
TL;DR: It is found that sterile wounding initiates an innate immune response that increases resistance to overt infection and microbial colonization through activation of the epidermal growth factor receptor.
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Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site.
TL;DR: It is shown that s-hemojuvelin is released by a proprotein convertase through the cleavage at a conserved polybasic RNRR site and could be one of the mediators of hepcidin regulation by iron.
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Longitudinal analysis of peripheral blood T cell receptor diversity in patients with systemic lupus erythematosus by next-generation sequencing
Dharma R. Thapa,Raffi Tonikian,Raffi Tonikian,Chao Sun,Mei Liu,Andrea Dearth,Michelle Petri,Francois Pepin,Ryan O Emerson,Ann Ranger +9 more
TL;DR: A significant decrease in T cell repertoire diversity was observed in PB of SLE patients compared to HC, and without a priori knowledge of disease-specific clones, monitoring TCR repertoire in PB from Sle patients is not likely to be useful to predict changes in disease activity.