Lide Liu

TL;DR: Human β-defensins mRNAs are expressed in excised surface and submucosal gland epithelia from non-CF and CF patients and data suggest that in the lung HBD-2 expression is induced by inflammation, whereas H BD-1 may serve as a defense in the absence of inflammation.

TL;DR: Members of the IFN-γ-inducible tripeptide motif Glu-Leu-Arg− CXC chemokines were antimicrobial against Escherichia coli and Listeria monocytogenes and suggest that, in tissues with mononuclear cell infiltration, IFN -γ-Inducible chemokine may reach concentrations necessary for microbicidal activity.

TL;DR: It is found that the growth factors important in wound healing, insulin-like growth factor I and TGF-α, induce the expression of the antimicrobial peptides/polypeptides human cationic antimicrobial protein hCAP-18/LL-37, human β-defensin 3, neutrophil gelatinase-associated lipocalin, and secretory leukocyte protease inhibitor in human keratinocytes.

TL;DR: It is confirmed that at micromolar concentrations human beta-defensin-2 has a broad spectrum of antimicrobial activity, with the striking exception of Staphylococcus aureus.

TL;DR: The HBD-2 gene is the first member of the human defensin family that is locally inducible by inflammation and located H BD-2 as the most centromeric of the genes.