V
Victoria Gabayan
Researcher at University of California, Los Angeles
Publications - 36
Citations - 4641
Victoria Gabayan is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Hepcidin & Anemia. The author has an hindex of 18, co-authored 35 publications receiving 4212 citations. Previous affiliations of Victoria Gabayan include University of California, Berkeley & Albert Einstein College of Medicine.
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Journal ArticleDOI
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Elizabeta Nemeth,Seth Rivera,Victoria Gabayan,Charlotte Keller,Sarah Taudorf,Bente Klarlund Pedersen,Tomas Ganz +6 more
TL;DR: These studies in human liver cell cultures, mice, and human volunteers indicate that IL-6 is the necessary and sufficient cytokine for the induction of hepcidin during inflammation and that the IL- 6-hepcid in axis is responsible for the hypoferremia of inflammation.
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Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
TL;DR: The central role of the hepcidin-ferroportin interaction in iron homeostasis is highlighted, with a rapid and sustained action of a single dose made it an appealing agent for the prevention of iron accumulation in hereditary hemochromatosis.
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Iron-transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
TL;DR: It is shown that holotransferrin concentrations regulate hepcidin mRNA concentrations through a hemojuvelin/BMP2/4-dependent pathway and will greatly facilitate studies of major disorders of iron homeostasis.
Journal ArticleDOI
Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of β-thalassemia.
Léon Kautz,Grace Jung,Xin Du,Victoria Gabayan,Justin Chapman,Marc Nasoff,Elizabeta Nemeth,Tomas Ganz +7 more
TL;DR: Erythroferrone mediates hepcidin suppression and contributes to iron overload in a mouse model of β-thalassemia, and slightly ameliorated ineffective erythropoiesis, but did not improve the anemia.
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Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
Emilio Ramos,Léon Kautz,Richard Rodriguez,Michael Hansen,Victoria Gabayan,Yelena Ginzburg,Marie-Paule Roth,Elizabeta Nemeth,Tomas Ganz +8 more
TL;DR: A model in which acute increases in holotransferrin concentrations transmitted through HFE, TfR2, and HJV augment BMP receptor sensitivity to BMPs is supported and a distinct regulatory mechanism that senses hepatic iron may modulate hepcidin response to chronic iron loading is proposed.