D
Dhruvitkumar S. Sutaria
Researcher at University of Florida
Publications - 28
Citations - 854
Dhruvitkumar S. Sutaria is an academic researcher from University of Florida. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 21 publications receiving 529 citations. Previous affiliations of Dhruvitkumar S. Sutaria include Ohio State University & Western University of Health Sciences.
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Journal ArticleDOI
Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells
Xiaohua Zhu,Mohamed Badawi,Steven M. Pomeroy,Dhruvitkumar S. Sutaria,Zhiliang Xie,Alice Baek,Jinmai Jiang,Ola A. Elgamal,Xiaokui Mo,Krista M. D. La Perle,Jeffrey J. Chalmers,Thomas D. Schmittgen,Mitch A. Phelps +12 more
TL;DR: This study provides a framework for assessment of immunogenicity and toxicity that will be required as EVs from varying cell sources are tested within numerous animal models and eventually in humans.
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Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading
Dhruvitkumar S. Sutaria,Dhruvitkumar S. Sutaria,Mohamed Badawi,Mitch A. Phelps,Thomas D. Schmittgen +4 more
TL;DR: This review focuses on describing the various published approaches for loading EVs with therapeutics, and two methods of loading of EVs with therapeutic cargo exist, endogenous and exogenous loading.
Journal ArticleDOI
Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery.
Dhruvitkumar S. Sutaria,Dhruvitkumar S. Sutaria,Jinmai Jiang,Ola A. Elgamal,Ola A. Elgamal,Steven M. Pomeroy,Mohamed Badawi,Xiaohua Zhu,Ryan E. Pavlovicz,Ana Clara P. Azevedo-Pouly,Jeffrey J. Chalmers,Chenglong Li,Mitch A. Phelps,Thomas D. Schmittgen +13 more
TL;DR: The TAT-TAR interaction enhanced the loading of the miR-199a into EVs by 65-fold and may be valuable in other drug delivery approaches involving miRNA mimics or other hairpin containing RNAs.
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Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen
Dhruvitkumar S. Sutaria,Balagangadhar Karthik Grandhi,Arvind Thakkar,Jeffrey Wang,Sunil Prabhu +4 more
TL;DR: The feasibility of using a solid lipid nanoparticulate system for the first time to deliver this novel combination chemoprevention regimen of aspirin, curcumin and free sulforaphane against pancreatic cancer cells is demonstrated, providing valuable evidence for the usability of nanotechnology-based drug regimens towards Pancreatic cancer chemiprevention.
Journal ArticleDOI
First Penicillin-Binding Protein Occupancy Patterns of β-Lactams and β-Lactamase Inhibitors in Klebsiella pneumoniae.
Dhruvitkumar S. Sutaria,Bartolome Moya,Kari B. Green,Tae Hwan Kim,Xun Tao,Yuanyuan Jiao,Arnold Louie,George L. Drusano,Jürgen B. Bulitta +8 more
TL;DR: The first PBP binding data on 13 chemically diverse and clinically relevant β-lactams and β- lactamase inhibitors in K. pneumoniae enable, for the first time, the rational design and optimization of double β-Lactam and β,lactam–β-lACTamase inhibitor combinations.