J
Jürgen B. Bulitta
Researcher at University of Florida
Publications - 169
Citations - 5803
Jürgen B. Bulitta is an academic researcher from University of Florida. The author has contributed to research in topics: Population & Pharmacokinetics. The author has an hindex of 38, co-authored 158 publications receiving 4878 citations. Previous affiliations of Jürgen B. Bulitta include Monash University & University of Cologne.
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Journal ArticleDOI
Resurgence of colistin: a review of resistance, toxicity, pharmacodynamics, and dosing.
Lauren M Lim,Neang S. Ly,Dana Anderson,Jenny C Yang,Laurie Macander,Anthony Jarkowski,Anthony Jarkowski,Alan Forrest,Jürgen B. Bulitta,Brian T. Tsuji +9 more
TL;DR: It is hypothesized that the PmrA‐PmrB and PhoP‐PhoQ genetic regulatory systems may play a role in resistance to colistin, and dosages must be optimized to achieve maximal efficacy and minimal toxicity.
Journal ArticleDOI
Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations.
TL;DR: Established and new sample preparation and analytical methods to measure bone concentrations and the extent and rate of bone penetration of antibacterials are compared, with a focus on studies conducted between 1998 and 2007.
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Pharmacokinetic/Pharmacodynamic Investigation of Colistin against Pseudomonas aeruginosa Using an In Vitro Model
TL;DR: The aims of this study were to identify the pharmacokinetic/pharmacodynamic (PK/PD) index that best predicts colistin efficacy and determine the values for the predictive PK/PD index required to achieve various magnitudes of killing effect.
Journal ArticleDOI
Population pharmacokinetics and pharmacodynamics of continuous versus short-term infusion of imipenem-cilastatin in critically ill patients in a randomized, controlled trial
Samir G. Sakka,Anna K. Glauner,Jürgen B. Bulitta,Martina Kinzig-Schippers,Wolfgang Pfister,George L. Drusano,Fritz Sörgel +6 more
TL;DR: This study studied 20 critically ill patients with nosocomial pneumonia and investigated whether continuous infusion with a reduced total dose, compared to the standard regimen of intermittent short-term infusion, results in a superior probability of target attainment as assessed by the fT>MIC value of imipenem.
Journal ArticleDOI
Attenuation of Colistin Bactericidal Activity by High Inoculum of Pseudomonas aeruginosa Characterized by a New Mechanism-Based Population Pharmacodynamic Model
Jürgen B. Bulitta,Jenny C Yang,Liliana Yohonn,Liliana Yohonn,Neang S. Ly,Silvia V. Brown,Rebecca E D'Hondt,William J. Jusko,Alan Forrest,Brian T. Tsuji,Brian T. Tsuji +10 more
TL;DR: The proposed mechanism-based model had a good predictive performance, could describe killing by colistin for all three studied strains and for two literature studies, and performed well in a prospective validation with various concentrations of Ca2+ and Mg2+.