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Ana Clara P. Azevedo-Pouly
Researcher at Ohio State University
Publications - 14
Citations - 429
Ana Clara P. Azevedo-Pouly is an academic researcher from Ohio State University. The author has contributed to research in topics: microRNA & Pancreatic cancer. The author has an hindex of 7, co-authored 10 publications receiving 337 citations. Previous affiliations of Ana Clara P. Azevedo-Pouly include University of Texas Southwestern Medical Center.
Papers
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Journal ArticleDOI
microRNA Replacement Therapy for Cancer
TL;DR: The field of oligonucleotide mimics and gene vector approaches to restore microRNA levels in tumors is surveyed and the literature on experimental and pre-clinical studies that have used these approaches to treat cancer is reviewed.
Journal ArticleDOI
Tumor Suppressive Function of mir-205 in Breast Cancer Is Linked to HMGB3 Regulation
Ola A. Elgamal,Jong Kook Park,Yuriy Gusev,Ana Clara P. Azevedo-Pouly,Jinmai Jiang,Avtar Roopra,Thomas D. Schmittgen +6 more
TL;DR: Findings suggest that modulating miR-205 and/or targeting HMGB3 are potential therapies for advanced breast cancer.
Journal ArticleDOI
Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery.
Dhruvitkumar S. Sutaria,Dhruvitkumar S. Sutaria,Jinmai Jiang,Ola A. Elgamal,Ola A. Elgamal,Steven M. Pomeroy,Mohamed Badawi,Xiaohua Zhu,Ryan E. Pavlovicz,Ana Clara P. Azevedo-Pouly,Jeffrey J. Chalmers,Chenglong Li,Mitch A. Phelps,Thomas D. Schmittgen +13 more
TL;DR: The TAT-TAR interaction enhanced the loading of the miR-199a into EVs by 65-fold and may be valuable in other drug delivery approaches involving miRNA mimics or other hairpin containing RNAs.
Journal ArticleDOI
Globally increased ultraconserved noncoding RNA expression in pancreatic adenocarcinoma
Jinmai Jiang,Ana Clara P. Azevedo-Pouly,Roxana S. Redis,Eun Joo Lee,Eun Joo Lee,Yuriy Gusev,David Allard,Dhruvitkumar S. Sutaria,Mohamed Badawi,Ola A. Elgamal,Megan R. Lerner,Daniel J. Brackett,Daniel J. Brackett,George A. Calin,Thomas D. Schmittgen +14 more
TL;DR: A global increase in expression of T-UCRs is reported in both human and mouse PDAC, suggesting a similar mechanism of transcriptional upregulation for T- UCRs in PDAC.
Journal ArticleDOI
RNA Isolation from Mouse Pancreas: A Ribonuclease-rich Tissue
TL;DR: Modifications of standard phenol/guanidine thiocyanate lysis reagent protocols to isolate RNA from mouse pancreas routinely isolate RNA with RNA Integrity Number (RIN) greater than 7.0 and is of suitable quality for routine gene expression analysis.