D
Dia C. Beachboard
Researcher at Duke University
Publications - 13
Citations - 649
Dia C. Beachboard is an academic researcher from Duke University. The author has contributed to research in topics: RNA & Pattern recognition receptor. The author has an hindex of 8, co-authored 12 publications receiving 553 citations. Previous affiliations of Dia C. Beachboard include University of Tennessee Health Science Center & Vanderbilt University Medical Center.
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Journal ArticleDOI
Innate immune evasion strategies of DNA and RNA viruses
TL;DR: This review will highlight recent advances in the understanding of the mechanisms by which viruses evade PRR detection, intermediate signaling molecule activation, transcription factor activation, and the actions of antiviral proteins.
Journal ArticleDOI
Distribution of Mycobacterium ulcerans in Buruli Ulcer Endemic and Non-Endemic Aquatic Sites in Ghana
Heather Williamson,Mark Eric Benbow,Khoa Nguyen,Dia C. Beachboard,Ryan Kimbirauskas,Mollie D. McIntosh,Charles Quaye,Edwin Ampadu,Daniel A. Boakye,Richard W. Merritt,Pamela L. C. Small +10 more
TL;DR: Results suggest that M. ulcerans is present in both endemic and non-endemic sites and that variable number tandem repeat (VNTR) profiling can be used to follow chains of transmission from the environment to humans, suggesting that focal demography, along with patterns of human water contact, may play a major role in transmission of Buruli ulcer.
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Murine hepatitis virus nonstructural protein 4 regulates virus-induced membrane modifications and replication complex function
Gadlage Mark Jacob,Jennifer S. Sparks,Dia C. Beachboard,Reagan G. Cox,Joshua D. Doyle,Christopher C. Stobart,Mark R. Denison +6 more
TL;DR: Electron microscopic analysis of ultrastructure from infected cells demonstrated that the nsp4 mutants had aberrant morphology of virus-induced double-membrane vesicles (DMVs) compared to those infected with wt virus, indicating that the structure of DMVs is essential for efficient RNA synthesis and optimal replication of coronaviruses.
Journal ArticleDOI
Dual analysis for mycobacteria and propionibacteria in sarcoidosis BAL.
Kyra Oswald-Richter,Dia C. Beachboard,Erin H. Seeley,Susamma Abraham,Bryan E. Shepherd,Cathy A. Jenkins,Daniel A. Culver,Richard M. Caprioli,Wonder P. Drake +8 more
TL;DR: MALDI-IMS localizes signals consistent with ESAT-6 to sarcoidosis granulomas, whereas no specific localization of P. acnes signals is detected, and these immunologic and molecular investigations support further investigation of the microbial community within sarCOidosisgranulomas.
Journal ArticleDOI
Multiple mycobacterial antigens are targets of the adaptive immune response in pulmonary sarcoidosis
Kyra Oswald-Richter,Dia C. Beachboard,Xiaoyan Zhan,Christa Gaskill,Susamma Abraham,Cathy A. Jenkins,Daniel A. Culver,Wonder P. Drake +7 more
TL;DR: Together these results reveal that antigen-specific CD4+ and CD8+ T cells responses to multiple mycobacterial epitopes are present within sites of active sarcoidosis involvement, and that these antigen- specific responses are present at the time of diagnosis.