D
Diana Juchter
Researcher at University of Virginia
Publications - 14
Citations - 540
Diana Juchter is an academic researcher from University of Virginia. The author has contributed to research in topics: Low-density lipoprotein & Cholesteryl ester. The author has an hindex of 12, co-authored 14 publications receiving 538 citations. Previous affiliations of Diana Juchter include University of Pennsylvania.
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Journal ArticleDOI
Trophic actions of human somatomedin C/insulin-like growth factor I on ovarian cells: in vitro studies with swine granulosa cells.
TL;DR: Human somatomedin C/IGF I exerts potent and specific differentiative effects on swine granulosa cells cultured under serum-free conditions in vitro, suggesting that protein and RNA synthesis are required for the full expression of somatamedin C's differentiatives effects.
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Synergistic actions of estradiol and the insulin-like growth factor somatomedin-C on swine ovarian (granulosa) cells.
Johannes D. Veldhuis,Raymond J. Rodgers,Richard W. Furlanetto,Paula Azimi,Diana Juchter,James C. Garmey +5 more
TL;DR: It is concluded that estradiol and somatomedin-C interact synergistically in a time- and dose-dependent manner to enhance the biosynthesis of pregnenolone and progesterone by swine granulosa cells.
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The insulin-like growth factor, somatomedin-C, modulates low density lipoprotein metabolism by swine granulosa cells.
Johannes D. Veldhuis,John E. Nestler,John E. Nestler,Jerome F. Strauss,Jerome F. Strauss,Paula Azimi,Paula Azimi,James C. Garmey,James C. Garmey,Diana Juchter,Diana Juchter +10 more
TL;DR: It is concluded that IGF-I and LDL synergistically enhance progesterone biosynthesis by ovarian cells in part via mechanisms that regulate the effectual delivery of lipoprotein-borne cholesterol substrate into cellular sterol pools that participate in steroid hormone biosynthesis.
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Insulin regulates low density lipoprotein metabolism by swine granulosa cells.
Johannes D. Veldhuis,John E. Nestler,Jerome F. Strauss,John T. Gwynne,Paula Azimi,James C. Garmey,Diana Juchter +6 more
TL;DR: It is concluded that insulin and LDL synergistically enhance progesterone biosynthesis by swine granulosa cells via specific mechanisms that depend upon 1,2,-cyclohexanedione-sensitive residues within LDL apoprotein.
Journal ArticleDOI
Bipotential Actions of Estrogen on Progesterone Biosynthesis by Ovarian Cells. I. Relation of Estradiol's Inhibitory Actions to Cholesterol and Progestin Metabolism in Cultured Swine Granulosa Cells*
TL;DR: It is concluded that suitable follicle selection and appropriate in vitro culture conditions provide a consistently estrogen-responsive granulosa-cell system, in which estradiol modulates certain key aspects of progestin and cholesterol metabolism.