D
Dick F. van Wichen
Researcher at Utrecht University
Publications - 20
Citations - 4102
Dick F. van Wichen is an academic researcher from Utrecht University. The author has contributed to research in topics: Heart failure & Heart transplantation. The author has an hindex of 16, co-authored 20 publications receiving 3978 citations.
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Journal ArticleDOI
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.
Journal ArticleDOI
The Chemokine and Chemokine Receptor Profile of Infiltrating Cells in the Wall of Arteries With Cardiac Allograft Vasculopathy Is Indicative of a Memory T–Helper 1 Response
Jorg van Loosdregt,Matthijs F.M. van Oosterhout,A.H. Bruggink,Dick F. van Wichen,Joyce van Kuik,Erica de Koning,Carla C. Baan,Nicolaas de Jonge,F.H.J. Gmelig-Meyling,Roel A. de Weger +9 more
TL;DR: In coronary arteries with CAV, most T cells are CD4+ and express human leukocyte antigen DR, and activated TH cells are mainly memory TH1 cells on the basis of their C+CR profile and cytokine expression.
Journal ArticleDOI
Left ventricular assist device in end-stage heart failure: Persistence of structural myocyte damage after unloading: An immunohistochemical analysis of the contractile myofilaments
Nicolaas de Jonge,Dick F. van Wichen,Marguerite E.I. Schipper,Jaap R. Lahpor,F.H.J. Gmelig-Meyling,Etienne O. Robles de Medina,Roel A. de Weger +6 more
TL;DR: After LVAD support, during a period of 213 +/- 135 days in patients with end-stage HF, severe structural myocyte damage persisted, and this does not support complete recovery of myocyte histologic features.
Journal ArticleDOI
Brain natriuretic peptide is produced both by cardiomyocytes and cells infiltrating the heart in patients with severe heart failure supported by a left ventricular assist device.
A.H. Bruggink,Nicolaas de Jonge,Matthijs F.M. van Oosterhout,Dick F. van Wichen,Erica de Koning,Jaap R. Lahpor,Hans Kemperman,F.H.J. Gmelig-Meyling,Roel A. de Weger +8 more
TL;DR: A significant decrease in serum BNP concentration after LVAD support coincides with a decrease in BNP mRNA and protein expression in the heart, which may play an important role in the reverse remodeling process of the heart.
Journal ArticleDOI
Adhesion molecule expression on skin endothelia in atopic dermatitis: Effects of TNF-α and IL-4
I.Jolanda M. de Vries,Elisabeth G. Langeveld-Wildschut,Frank C. van Reijsen,Gerald R. Dubois,J.Annet van den Hoek,I. C. Bihari,Dick F. van Wichen,Roel A. de Weger,Edward F. Knol,T. Thepen,Carla A.F.M. Bruijnzeel-Koomen +10 more
TL;DR: Adhesion molecule expression is increased in the skin of patients with AD, and most probably, this increased expression is not a (direct) effect of IL-4 on skin endothelium, but other cytokines, such as TNF-α, might be responsible for this increased adhesion molecules expression.