V
Vladimir Korinek
Researcher at Academy of Sciences of the Czech Republic
Publications - 75
Citations - 15445
Vladimir Korinek is an academic researcher from Academy of Sciences of the Czech Republic. The author has contributed to research in topics: Wnt signaling pathway & Beta-catenin. The author has an hindex of 28, co-authored 66 publications receiving 14542 citations. Previous affiliations of Vladimir Korinek include Utrecht University & Johns Hopkins University.
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Journal ArticleDOI
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Patrice J. Morin,Andrew B. Sparks,Vladimir Korinek,Nick Barker,Hans Clevers,Bert Vogelstein,Kenneth W. Kinzler +6 more
TL;DR: Results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β- catenin.
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Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma
Vladimir Korinek,Nick Barker,Patrice J. Morin,Dick F. van Wichen,Roel A. de Weger,Kenneth W. Kinzler,Bert Vogelstein,Hans Clevers +7 more
TL;DR: Constitutive transcription of Tcf target genes, caused by loss of APC function, may be a crucial event in the early transformation of colonic epithelium.
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XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
Miranda Molenaar,Marc van de Wetering,Mariëtte A. Oosterwegel,Josi Peterson-Maduro,Susan Godsave,Vladimir Korinek,Jeroen P. Roose,Olivier Destrée,Hans Clevers +8 more
TL;DR: It is proposed that signaling by beta-catenin involves complex formation with XT cf-3, followed by nuclear translocation and activation of specific XTcf-3 target genes, which suppresses endogenous axis specification upon injection into the dorsal blastomeres of a 4-cell-stage embryo.
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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.
Vladimir Korinek,Nick Barker,Petra Moerer,E van Donselaar,Gerwin Huls,Peter J. Peters,Hans Clevers +6 more
TL;DR: The role of Tcf-4 in colon cancer was investigated in this paper, where the authors found that Tcf7/2//- mice die shortly after birth from colon cancer.
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Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway
V. J. M. Wielenga,Ron Smits,Vladimir Korinek,L. Smit,Menno F. Kielman,Riccardo Fodde,Hans Clevers,Steven T. Pals +7 more
TL;DR: In this paper, the authors analyzed CD44 expression in the intestinal mucosa of mice and humans with genetic defects in either APC or Tcf-4, leading to constitutive activation or blockade of the β-catenin/Tcf4 pathway, respectively.