Diego Iacono

TL;DR: Orexin signaling promotes obesity resistance via enhanced spontaneous physical activity and energy expenditure regulation and the deficiency/dysfunction in orexins system lead to obesity in animal models despite of lower calories intake than wildtype associated with reduced physical activity.

TL;DR: The hypothesis is that in migraine a dysfunction of orexinergic projections on the median raphe (MR) nuclei, interfering with serotonergic regulation, may cause Non-Rapid Eye Movement parasomnias, such as somnambulism.

TL;DR: This study shows the clinical relevance of the burden carried by the mothers of children affected by DD and suggests the importance to assess parents, particularly mothers, to improve family compliance and clinical management of this disorder.

TL;DR: The findings show a reduction of arousability in MoA group and lower NREM lower sleep instability associated with MoA in children.

TL;DR: The findings of this initial investigation seem to support a major role of Orexin-A in sleep organization alterations in children with FNFRI and suggest that sleep habits evaluation should be considered as screening and complementary tool for the diagnosis of fecal incontinence in children.