Dimitra Klapsa

TL;DR: It is concluded that viral RNA sequences found in sewage closely resemble those from clinical samples and that environmental surveillance can be used to monitor SARS-CoV-2 transmission, tracing virus variants and detecting virus importations.

TL;DR: The results in virus neutralization assays with human sera and immunisation-challenge experiments using transgenic mice expressing the human poliovirus receptor indicate that while maintaining high immunisation coverage will likely confer protection against paralytic disease caused by these viruses, significant changes in immunisation strategies might be required to effectively stop their occurrence and potential widespread transmission.

TL;DR: It is shown how the next-generation sequencing approach can be used for the early detection of emerging pathogens and to improve the understanding of enterovirus circulation in humans.

TL;DR: In this article, the authors investigated the use of environmental surveillance (ES) for the rapid detection and quantification of B.1.7 viruses in sewage as a way of monitoring its expansion that is independent on the investigation of identified clinical cases.

TL;DR: A novel ES approach using next-generation sequencing (NGS) to identify HEVs in sewage samples collected in London, United Kingdom, from June 2016 to May 2017 has high sensitivity for polio and non-PV HEV detection, generating nearly whole-genome sequence information.