D
Dimitrios Tsikas
Researcher at Hannover Medical School
Publications - 19
Citations - 691
Dimitrios Tsikas is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Asymmetric dimethylarginine & Nitric oxide. The author has an hindex of 9, co-authored 19 publications receiving 664 citations. Previous affiliations of Dimitrios Tsikas include Silesian University & Jagiellonian University.
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Journal ArticleDOI
Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension.
Andrzej Surdacki,Michał Nowicki,Joerg Sandmann,Dimitrios Tsikas,Rainer H Boeger,Stephanie M. Bode-Boeger,Olga Kruszelnicka-Kwiatkowska,Franciszek Kokot,Jacek S. Dubiel,Juergen C Prof Dr Med Froelich +9 more
TL;DR: In male subjects with EH, endogenous systemic NO formation appears depressed, which is unrelated to accompanying insulin resistance or dyslipidemia, and circulating methylated analogs of L-arginine levels are increased in uncomplicated EH which may be of potential relevance.
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Lack of oxidative stress during sustained therapy with isosorbide dinitrate and pentaerythrityl tetranitrate in healthy humans: a randomized, double-blind crossover study.
Roland Keimer,Friederike K. Stutzer,Dimitrios Tsikas,Raphael Troost,Frank-Mathias Gutzki,Jürgen C. Frölich +5 more
TL;DR: This study is compatible with a stimulation of cGMP by ISDN, but neither ISDN nor PETN enhances systemic oxidative stress in healthy volunteers.
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Accurate quantification of basal plasma levels of 3-nitrotyrosine and 3-nitrotyrosinoalbumin by gas chromatography-tandem mass spectrometry.
Dimitrios Tsikas,Edzard Schwedhelm,Friedericke K. Stutzer,Frank Gutzki,Iris Rode,Christina Mehls,Jürgen C. Frölich +6 more
TL;DR: In this paper, an interference-free GC-tandem MS-based method was proposed to quantify protein-associated 3-nitro- l -[2H3]tyrosine in human plasma, which yielded the lowest basal plasma NO2Tyr levels reported thus far.
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Mass Spectrometric Analysis of F2-Isoprostanes: Markers and Mediators in Human Disease
TL;DR: To meet increasing interest in isoprostanes as valid and stable markers of oxidative stress in human disease, results from various clinical trials in the cardiovascular field are discussed and relevant experimental findings as well as potential direct effects of isop frostanes in these pathophysiological settings are reviewed.
Journal ArticleDOI
Asymmetric dimethylarginine in children with homocystinuria or phenylketonuria
Nele Kanzelmeyer,Dimitrios Tsikas,Kristine Chobanyan-Jürgens,Bibiana Beckmann,Bernhard Vaske,Sabine Illsinger,Anibh M. Das,Thomas Lücke +7 more
TL;DR: The study shows that the l-arginine/NO pathway is differently altered in children with phenylketonuria and homocystinuria, and indicates enhanced DDAH activity in this disease.