There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.

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Controlled drug delivery vehicles for cancer treatment and their performance.

Hydrogels for biomedical applications.

W213 Therapeutic interventions of aegeline for insulin resistance and type 2 diabetes: biological application through scientific research data analysis and molecular mechanism

Biological effect of eriocitrin on oxidative damage: Therapeutic potential through scientific data analysis

T008 Therapeutic importance of astilbin for the treatment of renal injury and hyperuricemia: Biological importance of xanthine oxidase in the kidney disorders



Medicinal plants and their derived products have been used in the medical field for the treatment of human diseases from a very early age. Phytoproducts, including numerous pure phytoconstituents have been used for the treatment of human health complications. Coumarin is a pure phytoconstituent of benzopyrone family derivatives. Fraxin is a coumarin glucoside found to be present in the bark of Fraxinus excelsior L. Fraxin has numerous physiological functions in medicine mainly due to its anti-inflammatory, anti-oxidant, hepatoprotective and analgesic activity.



The present review mainly focuses on the medicinal importance, pharmacological activities and analytical aspects of fraxin. Pharmacological activities of fraxin have been reviewed in the present work through literature data analysis of different scientific research works. Analytical methods developed for the qualitative and quantitative analysis of fraxin in herbal drugs have been reviewed in the present work through scientific data analysis of different research works. Electronic databases such as PubMed, Science Direct, Google Scholar and Scopus have been searched in the present work in order to collect scientific information on fraxin.



Present paper summarized the biological importance, therapeutic benefit and pharmacological activities of fraxin in medicine. Scientific data analysis of different literature work revealed the biological importance and therapeutic benefit of fraxin in medicine. The biological importance of fraxin in medicine was mainly due to its significant effect on acute respiratory distress syndrome, hepatotoxicity, inflammation, oxidative stress, acute kidney injury, osteoarthritis, liver damage and tumor. Further pharmacokinetic data on fraxin were also collected and discussed in the present work to know the plasma drug concentration profile of fraxin. Analytical data of the present paper will be beneficial for the development of newer and effective analytical tools for the quantitative estimation of fraxin in different biological samples. However, scientific experiments on fraxin in the clinical use should be developed to scientifically validate the medicinal uses of fraxin.



Present paper will be beneficial to all the scientific people in the biological field to know the therapeutic benefit of fraxin against various forms of human disorders.


An Overview of Medicinal Importance, Pharmacological Activities and Analytical Aspects of Fraxin from Cortex fraxinus



Psoralea corylifolia L. is an important herbal medicine mainly used for the treatment of coronary artery disease, osteoporosis, bacterial infections, vitiligo, and psoriasis. P. corylifolia contains numerous active phytochemicals including bavachalcone. Polyphenolic compounds, including flavonoidal class phytochemicals are secondary plant metabolites found to be present in numerous plant species and reported to have multiple functions to counteract free radicals.



The aim of the present study is to review the medicinal importance and pharmacological activities of bavachalcone. To know the therapeutic benefit of bavachalcone in medicine, here in the present work we have attempted to provide scientific information of bavachalcone. The present paper has been divided into the overview of flavonoids and P. corylifolia, pharmacological activities of bavachalcone, and analytical aspects of bavachalcone. Detailed pharmacological activities of bavachalcones have been discussed in the present paper. Further Bioanalytical aspects have been also discussed for development of analytical techniques for separation, isolation, and identification of bavachalcone. In the present work, numerous scientific databases such as PubMed, Science Direct, Scopus, Google Scholar, and Google have been searched.



Scientific data analysis revealed that bavachalcone is an important phytochemicals, found to be present in P. corylifolia. Scientific data analysis revealed the biological importance and therapeutic benefit of bavachalcone in medicine. Pharmacological data analysis revealed their effectiveness against cancer, oxidative stress, Alzheimer's disease, angiogenesis, tissue repair, osteoclastogenesis and various enzymes. Further pharmacokinetic and analytical data of bavachalcone have been also collected and analyzed in the present work.



Scientific data analysis revealed that several molecular mechanisms are responsible for pharmacological activities of bavachalcone.


Dinesh K. Patel

Papers

W213 Therapeutic interventions of aegeline for insulin resistance and type 2 diabetes: biological application through scientific research data analysis and molecular mechanism

Biological effect of eriocitrin on oxidative damage: Therapeutic potential through scientific data analysis

T008 Therapeutic importance of astilbin for the treatment of renal injury and hyperuricemia: Biological importance of xanthine oxidase in the kidney disorders

An Overview of Medicinal Importance, Pharmacological Activities and Analytical Aspects of Fraxin from Cortex fraxinus

Therapeutic application of Bavachalcone in chronic diseases: A concise report on medicinal importance and pharmacological activities