Diogo Kuczera

TL;DR: Naringenin is a suitable candidate molecule for the development of specific dengue virus treatments and was demonstrated in primary human monocytes infected with d Dengue virus sertoype-4, supporting the potential use of naringen in to control denge virus replication.

TL;DR: It is demonstrated that the citrus flavanone naringenin (NAR) prevented ZikV infection in human A549 cells in a concentration-dependent and ZIKV-lineage independent manner, and a molecular docking analysis suggests a potential interaction between NAR and the protease domain of the NS2B-NS3 protein of ZIKv which could explain the anti-ZIKV activity of NAR.

TL;DR: It is demonstrated that AgNp-bio had a direct effect against L. amazonensis forms and acted on immunomodulatory ability of infected macrophages, reducing the infection without inducing the synthesis of inflammatory mediators, which continuous stimulation can generate and aggravate leishmaniotic lesions.

TL;DR: Light is shed on how the cytokine network signature elicited, in association with viral aspects deserves special attention regarding the establishment of infection and evolution to pathogenesis in severe dengue development.

TL;DR: It is shown that EVs derived from cells treated with IFN alpha have a protective effect against DENV infection in other cells, although immune mechanisms to counteract viral infection can also involve DC-derived EVs.