The remarkable diversity of techniques available for the construction of glycoproteins is presented. The complexity of synthesis is still an issue but by judicious and combined use of some of the complementary techniques, practical synthesis of complex glycoproteins will be achieved. Since glycosylation has an important role in correct protein folding, it is unlikely to be enough to "just make it", and in this regard the timing of glycosylation and assembly strategy in any synthesis may too become a vital issue.

/pdf/synthesis-of-glycoproteins-31v9s247lo.pdf

Synthesis of glycoproteins.

Antiviral activities of lactoferrin

Recombinant lipoproteins: lipoprotein-like lipid particles for drug targeting.

Glycotargeting relies on carrier molecules possessing carbohydrates that are recognized and internalized by cell surface mammalian lectins. Numerous types of glycotargeting vehicles have been designed based on the covalent attachment of saccharides to proteins, polymers and other aglycones. These carriers have found their major applications in antiviral therapy, immunoactivation, enzyme replacement therapy and gene therapy. This review compares different types of glycotargeting agents and the lectins which have been successfully targeted to treat both model and human diseases. It may be concluded that the discovery of new mammalian lectins which endocytose their ligands will lead to the rapid development of new glycotargeting agents founded on the principles of carbohydrate-protein interactions.

Receptor mediated glycotargeting

The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake.

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.1840180122

Dirk K. F. Meije

Papers

Coupling of the antiviral drug ara-AMP to lactosaminated albumin leads to specific uptake in rat and human hepatocytes