T
Theo J.C. Van Berkel
Researcher at Leiden University
Publications - 319
Citations - 20609
Theo J.C. Van Berkel is an academic researcher from Leiden University. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 69, co-authored 317 publications receiving 19414 citations. Previous affiliations of Theo J.C. Van Berkel include Erasmus University Rotterdam & Loyola University Medical Center.
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Journal ArticleDOI
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Hiroshi Suzuki,Hiroshi Suzuki,Yukiko Kurihara,Motohiro Takeya,Nobuo Kamada,Motoyukl Kataoka,Kou-ichi Jishage,Otoya Ueda,Hisashl Sakaguchi,Takayuki Higashi,Tsukasa Suzuki,Yoshiaki Takashima,Yoshiki Kawabe,Yoshiki Kawabe,Osamu Cynshi,Youichiro Wada,Makoto Honda,Hiroki Kurihara,Hiroyuki Aburatani,Takefumi Doi,Akiyo Matsumoto,Sadahiro Azuma,Tetsuo Noda,Yutaka Toyoda,Hiroshige Itakura,Yoshio Yazaki,Seikoh Horiuchi,Kiyoshi Takahashi,J. Kar Kruijt,Theo J.C. Van Berkel,Urs P. Steinbrecher,Shun Ishibashi,Nobuyo Maeda,Siamon Gordon,Tatsuhiko Kodama +34 more
TL;DR: It is shown that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E, indicating that MSr-A may play a part in host defence against pathogens.
Journal ArticleDOI
Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
Jayaprakash K. Nair,Jennifer L. S. Willoughby,Amy Chan,Klaus Charisse,Md. Rowshon Alam,Qianfan Wang,Menno Hoekstra,Pachamuthu Kandasamy,Alexander V Kel'in,Stuart Milstein,Nate Taneja,Jonathan O'Shea,Sarfraz Shaikh,Ligang Zhang,Ronald J. van der Sluis,Michael E. Jung,Akin Akinc,Renta Hutabarat,Satya Kuchimanchi,Kevin Fitzgerald,Tracy Zimmermann,Theo J.C. Van Berkel,Martin Maier,Kallanthottathil G. Rajeev,Muthiah Manoharan +24 more
TL;DR: The optimally chemically modified siRNA-GalNAc conjugates are hepatotropic and long-acting and have the potential to treat a wide range of diseases involving liver-expressed genes.
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Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock
TL;DR: The role of individual receptors such as the toll-like receptors and CD14 in the induction of proinflammatory cytokines and adhesion molecules is discussed in detail in this article, and the roles of other receptors that bind bacterial compounds such as scavenger receptors and their modulating role in inflammation are described.
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Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock
TL;DR: The role of individual receptors such as the toll-like receptors and CD14 in the induction of proinflammatory cytokines and adhesion molecules is discussed in detail and the therapies for the treatment of bacterial sepsis and septic shock are discussed in relation to the action of these receptors and proteins.
Journal ArticleDOI
The influence of cytokines on the integrity of the blood-brain barrier in vitro
Helga E. de Vries,M. C. M. Blom-Roosemalen,Marijke van Oosten,Albert G. de Boer,Theo J.C. Van Berkel,Douwe D. Breimer,Johan Kuiper +6 more
TL;DR: In conclusion, cytokines induce a disruption of the BBB in vitro and cyclooxygenase activation within the endothelial cells seems to play a key role.