Dmitri A. Pissarnitski

TL;DR: In this article, a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds and methods of treatment, prevention, inhibition, or amelioration of one or multiple diseases associated with the central nervous system using such compounds or pharmaceutical compositions are described.

TL;DR: In this article, the gamma secretase inhibitors of the formula were described, where R 1 is a substituted aryl or substituted heteroaryl group; R 2 is an R 1 group, alkyl, X(CO)Y, or alkylene-X( CO)Y wherein X and Y are as defined as defined herein; each R 3 and each r 3A are independently H, or Alkyl.

TL;DR: In this article, the gamma secretase inhibitors of the formula were disclosed. And a method of treating Alzheimer s Disease was also disclosed, which is a method for treating Alzheimer's Disease.

TL;DR: In this paper, a 2-Cyano Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are defined as defined herein.

TL;DR: Cyclic hydroxyamidines were designed and validated as isosteric replacements of the amide functionality and applied in the identification of γ-secretase modulators leading to highly efficacious agents for reduction of central nervous system Aβ in various animal models.