Vishal Verma

TL;DR: Improved transporters that can deliver agents in a superior fashion compared with naturally occurring cell-penetrating peptides and that can be synthesized in a practical and step-economical fashion are generated.

TL;DR: A framework for the selective modulation of ABC transporters is established and provides rational avenues for the design of new antibiotics and other therapeutics targeting this protein family.

TL;DR: Interestingly, the degree of Her‐2/neu oncogene expression in a panel of breast cancer cell lines was predictive of sensitivity to chemical FAS inhibitors‐induced cytotoxicity, while low‐FAS expressing and chemical Fas inhibitors‐resistant MDA‐MB‐231 breast cancer cells became hypersensitive to FAS blockade.

TL;DR: This study illustrates the application of function-oriented synthesis to the design and synthesis of functional analogs of the bryostatin marine natural products, specifically directed at exploring the activity-determining role of brystatin A-ring functionality on PKC affinity and selectivity.

TL;DR: Activity provides a molecular explanation for the potent antiproliferative effects of bistramide A, identifying it as a new biochemical tool for studies of the actin cytoskeleton and as a potential lead for development of a new class of antitumor agents.