D
Dmitry A. Stetsenko
Researcher at Novosibirsk State University
Publications - 111
Citations - 1729
Dmitry A. Stetsenko is an academic researcher from Novosibirsk State University. The author has contributed to research in topics: Oligonucleotide & Phosphoramidite. The author has an hindex of 20, co-authored 107 publications receiving 1489 citations. Previous affiliations of Dmitry A. Stetsenko include Russian Academy of Sciences & University of Surrey.
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Journal ArticleDOI
Efficient conjugation of peptides to oligonucleotides by "native ligation".
TL;DR: Functionalized peptides and oligonucleotides were used without purification in native ligation conjugation reactions in aqueous/organic solution using tris-(2-carboxyethyl)phosphine to remove the tert-butylsulfenyl group in situ and thiophenol as a conjugations enhancer.
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Synthesis of peptide-oligonucleotide conjugates with single and multiple peptides attached to 2'-aldehydes through thiazolidine, oxime, and hydrazine linkages
Timofei S. Zatsepin,Dmitry A. Stetsenko,Andrey A. Arzumanov,Elena A. Romanova,Michael J. Gait,Tatiana S. Oretskaya +5 more
TL;DR: A 12-mer 2'-O-methyloligoribonucleotide complementary to the HIV-1 T AR RNA stem-loop and containing two conjugated copies of an 8-mer model laminin peptide was hardly affected in TAR RNA binding and showed a similar level of inhibition of HIV- 1 Tat-dependent in vitro transcription.
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Use of carbonyl group addition--elimination reactions for synthesis of nucleic acid conjugates.
TL;DR: This review outlines the synthesis of covalent conjugates of oligonucleotides and their analogues that are obtained by reactions of carbonyl compounds with various nucleophiles such as primary amines, N-alkoxyamines, hydrazines, and hydrazides.
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1-(Phenylethynyl)pyrene and 9,10-Bis(phenylethynyl)anthracene, Useful Fluorescent Dyes for DNA Labeling: Excimer Formation and Energy Transfer
Andrei D. Malakhov,Mikhail V. Skorobogatyi,Igor A. Prokhorenko,Sergei V. Gontarev,D. T. Kozhich,Dmitry A. Stetsenko,Irina A. Stepanova,Zakhar O. Shenkarev,Yuri A. Berlin,Vladimir A. Korshun +9 more
TL;DR: A series of modifying reagents, including phosphoramidites and solid supports, have been synthesized, and used for the introduction of 1-(phenylethynyl)pyrene (PEPy) and 9,10-bis(phenylethsynyl)-anthracene (BPEA) fluorescent dyes into predetermined positions of synthetic oligonucleotides.
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DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes.
TL;DR: In comparison with antisense oligonucleotides and small interfering RNAs, Dzs do not usually show off-target effects due to their high specificity and lack of immunogenicity in vivo, so there is a good chance that a deoxyribozyme drug reaching the clinic in the near future.