D
Doenja M. J. Lambregts
Researcher at Maastricht University Medical Centre
Publications - 45
Citations - 2622
Doenja M. J. Lambregts is an academic researcher from Maastricht University Medical Centre. The author has contributed to research in topics: Chemoradiotherapy & Colorectal cancer. The author has an hindex of 25, co-authored 45 publications receiving 2248 citations. Previous affiliations of Doenja M. J. Lambregts include Fudan University & Netherlands Cancer Institute.
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Journal ArticleDOI
Diffusion-Weighted MRI for Selection of Complete Responders After Chemoradiation for Locally Advanced Rectal Cancer: A Multicenter Study
Doenja M. J. Lambregts,Vincent Vandecaveye,Brunella Barbaro,Frans C. H. Bakers,Maarten Lambrecht,Monique Maas,Karin Haustermans,Vincenzo Valentini,Geerard L. Beets,Regina G. H. Beets-Tan +9 more
TL;DR: Addition of DWI to standard rectal MRI improves the selection of complete responders after chemoradiation and helps to consider these complete responders for less invasive treatments instead of standard surgery.
Journal ArticleDOI
Assessment of Clinical Complete Response After Chemoradiation for Rectal Cancer with Digital Rectal Examination, Endoscopy, and MRI: Selection for Organ-Saving Treatment.
Monique Maas,Doenja M. J. Lambregts,Patty J. Nelemans,Luc A. Heijnen,Milou H. Martens,Jeroen W. A. Leijtens,Meindert N. Sosef,Karel W.E. Hulsewé,Christiaan Hoff,Stephanie O. Breukink,Laurents P. S. Stassen,Regina G. H. Beets-Tan,Geerard L. Beets +12 more
TL;DR: Clinical assessment afterCRT is the single most accurate modality for identification of CR after CRT, and addition of MRI with DWI further improves the diagnostic performance, and the combination can be recommended as the optimal strategy for a safe and accurate selection of CRafter CRT.
Journal ArticleDOI
Tumour ADC measurements in rectal cancer: effect of ROI methods on ADC values and interobserver variability
Doenja M. J. Lambregts,Geerard L. Beets,Monique Maas,Luís Curvo-Semedo,Alfons G.H. Kessels,Thomas Thywissen,Regina G. H. Beets-Tan +6 more
TL;DR: ROI size and positioning have a considerable influence on tumour ADC values and interobserver variability and Tumour ADC measurements are more reproducible before, rather than after, chemoradiation treatment.
Journal ArticleDOI
Diffusion-weighted MRI in rectal cancer: apparent diffusion coefficient as a potential noninvasive marker of tumor aggressiveness.
Luís Curvo-Semedo,Doenja M. J. Lambregts,Monique Maas,Geerard L. Beets,Filipe Caseiro-Alves,Regina G. H. Beets-Tan,Regina G. H. Beets-Tan +6 more
TL;DR: To assess the value of diffusion‐weighted MR imaging (DWI) as a potential noninvasive marker of tumor aggressiveness in rectal cancer, by analyzing the relationship between tumoral apparent diffusion coefficient (ADC) values and MRI and histological prognostic parameters.
Journal ArticleDOI
Accuracy of Gadofosveset-enhanced MRI for Nodal Staging and Restaging in Rectal Cancer
Doenja M. J. Lambregts,Geerard L. Beets,Monique Maas,Alfons G.H. Kessels,Frans C. H. Bakers,Vincent C. Cappendijk,Sanne M. E. Engelen,Max J. Lahaye,Adriaan P. de Bruïne,Guido Lammering,Tim Leiner,Jan L. Verwoerd,Joachim E. Wildberger,Regina G. H. Beets-Tan +13 more
TL;DR: This study shows high reproducibility and significantly improved accuracy compared to standard MRI for gadofosveset-enhanced MRI for nodal staging and restaging in rectal cancer.