J
Jeroen W. A. Leijtens
Publications - 39
Citations - 2893
Jeroen W. A. Leijtens is an academic researcher. The author has contributed to research in topics: Medicine & Colorectal cancer. The author has an hindex of 15, co-authored 28 publications receiving 2089 citations.
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Journal ArticleDOI
Wait-and-See Policy for Clinical Complete Responders After Chemoradiation for Rectal Cancer
Monique Maas,Regina G. H. Beets-Tan,Doenja M. J. Lambregts,Guido Lammering,Patty J. Nelemans,Sanne M. E. Engelen,Ronald M. van Dam,Rob L. H. Jansen,Meindert N. Sosef,Jeroen W. A. Leijtens,Karel W.E. Hulsewé,Jeroen Buijsen,Geerard L. Beets +12 more
TL;DR: A wait-and-see policy with strict selection criteria, up-to-date imaging techniques, and follow-up is feasible and results in promising outcome at least as good as that of patients with a pCR after surgery.
Journal ArticleDOI
Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study
Maxime J M van der Valk,Maxime J M van der Valk,Denise E. Hilling,Denise E. Hilling,Esther Bastiaannet,Elma Meershoek-Klein Kranenbarg,Geerard L. Beets,Geerard L. Beets,Nuno Figueiredo,Angelita Habr-Gama,Rodrigo Oliva Perez,Andrew G Renehan,Andrew G Renehan,Cornelis J.H. van de Velde,Madeleine Ahlberg,Ane L Appelt,Oktar Asoglu,Maria-Theresa Bär,Rita Barroca,Regina G. H. Beets-Tan,Eric Belgers,Robbert J I Bosker,Stephanie O. Breukink,Krysztof Bujko,Carlos Carvalho,Christopher M. Cunningham,Ben Creavin,André D’Hoore,Jean-Pierre Gerard,Simon Gollins,Christiaan Hoff,Fabian A. Holman,Britt J. P. Hupkens,Soledad Iseas,Anders Jakobsen,Amir Keshvari,Sietze A Koopal,Miranda Kusters,Melanie Langheinrich,Jeroen W. A. Leijtens,Monique Maas,Lee Malcomson,Zamam Z Mamedli,Anna Martling,Klaus E. Matzel,Jarno Melenhorst,María L Morici,Sthela M. Murad-Regadas,Sarah T O'Dwyer,Koen C.M.J. Peeters,Isadora Rosa,Gustavo Rossi,Harm J. T. Rutten,Fernando Sanchez Loria,Marit E van der Sande,Guilherme Pagin São Julião,Mark P Saunders,Arthur Sun Myint,Hedwig van der Sluis,Renaud Schiappa,Nigel Scott,Jan H.M.B. Stoot,A Koen Talsma,Isabelle Terrasson,Handan Tokmak,Carlos A. Vaccaro,Alexander L Vahrmeijer,Daria K Wasowicz,Henderik L Westreenen,Des C. Winter,Albert Wolthuis,David D. E. Zimmerman +71 more
TL;DR: This dataset has the largest series of patients with rectal cancer treated with a W&W approach, consisting of approximately 50% data from previous cohort series and 50% unpublished data.
Journal ArticleDOI
Long-term Outcome of an Organ Preservation Program After Neoadjuvant Treatment for Rectal Cancer.
Milou H. Martens,Monique Maas,Luc A. Heijnen,Doenja M. J. Lambregts,Jeroen W. A. Leijtens,Laurents P. S. Stassen,Stephanie O. Breukink,Christiaan Hoff,Eric J. Belgers,Jarno Melenhorst,Robertus Jansen,Johannes Buijsen,Ton G. M. Hoofwijk,Regina G. H. Beets-Tan,Geerard L. Beets +14 more
TL;DR: Organ preservation appears oncologically safe for selected rectal cancer patients with a cCR or near cCR after neoadjuvant chemoradiation when applying strict selection criteria and frequent follow-up, including endoscopy and MRI.
Journal ArticleDOI
Assessment of Clinical Complete Response After Chemoradiation for Rectal Cancer with Digital Rectal Examination, Endoscopy, and MRI: Selection for Organ-Saving Treatment.
Monique Maas,Doenja M. J. Lambregts,Patty J. Nelemans,Luc A. Heijnen,Milou H. Martens,Jeroen W. A. Leijtens,Meindert N. Sosef,Karel W.E. Hulsewé,Christiaan Hoff,Stephanie O. Breukink,Laurents P. S. Stassen,Regina G. H. Beets-Tan,Geerard L. Beets +12 more
TL;DR: Clinical assessment afterCRT is the single most accurate modality for identification of CR after CRT, and addition of MRI with DWI further improves the diagnostic performance, and the combination can be recommended as the optimal strategy for a safe and accurate selection of CRafter CRT.
Journal ArticleDOI
Long-term Oncological and Functional Outcomes of Chemoradiotherapy Followed by Organ-Sparing Transanal Endoscopic Microsurgery for Distal Rectal Cancer: The CARTS Study
Rutger C.H. Stijns,Eelco J. R. de Graaf,Cornelis J. A. Punt,Iris D. Nagtegaal,Joost J. Nuyttens,Esther van Meerten,Pieter J. Tanis,Ignace H. J. T. de Hingh,George P. van der Schelling,Yair Acherman,Jeroen W. A. Leijtens,Andreas J A Bremers,Geerard L. Beets,Christiaan Hoff,Cornelis Verhoef,Corrie A.M. Marijnen,Johannes H. W. de Wilt +16 more
TL;DR: In early-stage rectal cancer (cT1-3N0M0), CRT enables organ preservation with additional TEM surgery in approximately two-thirds of patients with good long-term oncological outcome and HRQL, and this multimodality treatment triggers a certain degree of bowel dysfunction.