Dolores Vilella

TL;DR: The discovery of a nonpeptidyl fungal metabolite (L-783,281) that acted as an insulin mimetic in several biochemical and cellular assays demonstrates the feasibility of discovering novel insulin receptor activators that may lead to new therapies for diabetes.

TL;DR: A resorcylic acid lactone, L-783,277, isolated from a Phoma sp.

TL;DR: Several new, two-step, high-yielding absorption/elution methods of isolation based on reverse-phase chromatography at pH 8 that are applicable to scales from one gram to potential industrial quantities are developed.

TL;DR: Integric acid, a novel eremophilane sesquiterpenoid, was discovered from the screening of natural product libraries and inhibited 3′ -end processing, strand transfer and disintegration reactions catalyzed by HIV-1 integrase with IC50 values of 3–10 μM.

TL;DR: Ten different families of compounds are identified, all of which selectively inhibit FPTase with a variety of mechanisms, which originated from the fermentations of a number of microorganisms, either actinomycetes or fungi, isolated from different substrates collected in tropical and temperate areas.