Domenica Musumeci

TL;DR: Various approaches recently proposed in the literature to inhibit HMGB1 and the related inflammatory processes are described, especially focusing on the block of RAGE-HMGB1 signaling.

TL;DR: Recent advancements in SELEX technology for the efficient and rapid identification of new candidate aptamers (introduction of microfluidic systems and next generation sequencing) and discovery of several G4-forming motifs in important regulatory regions of the human or viral genome bound by endogenous proteins are reviewed.

TL;DR: The thrombin binding aptamers (TBAs) are analyzed as a model system to study multiple-aptamer constructs aimed at improving their anticoagulation activity in terms of binding to the target and stability to enzymatic degradation.

TL;DR: This review describes the isolation from marine organisms of all secosteroids reported in the literature from 1972 to 2004 and gives details on the biological activities of the isolated secosteroid (e.g. antiproliferative, antifouling, antiinflammatory, antimicrobial, ichthyotoxic and antiviral).

TL;DR: An updated overview on fluorescent DNA aptamers, designed to recognize significant cancer biomarkers both in soluble or membrane-bound form are reported, producing tumour-type specific, non-invasive in vivo imaging tools for cancer pre- and post-treatment assessment.