Domenico Coppola

TL;DR: In vitro data indicate that the combination of capecitabine and temozolomide is synergistic for induction of apoptosis in neuroendocrine tumor cell lines.

TL;DR: Findings indicate thatmiR-221 and miR-222 play a significant role in the regulation of ER α expression at the protein level and could be potential targets for restoring ERα expression and responding to antiestrogen therapy in a subset of breast cancers.

TL;DR: Elevated kinase levels of AKT2 and phosphatidylinositol-3-OH kinase (PI3K) in 32 of 80 primary breast carcinomas indicate that regulation between the ERalpha and PI3K/AKT2 pathway may play an important role in pathogenesis of human breast cancer and could contribute to ligand-independent breast cancer cell growth.

TL;DR: Molecular staging identifies patient prognosis more accurately than the traditional clinical staging, particularly for intermediate Dukes' stage B and C patients, with the potential to direct adjuvant therapy.

TL;DR: Evidence is presented that miR-155 is a critical therapeutic target in breast cancer because of its role in regulation of cell survival and chemosensitivity through down-regulation of FOXO3a in breast cancers.