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Aejaz Nasir
Researcher at Eli Lilly and Company
Publications - 76
Citations - 2676
Aejaz Nasir is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Cancer & Neuroendocrine tumors. The author has an hindex of 23, co-authored 74 publications receiving 2391 citations. Previous affiliations of Aejaz Nasir include University of South Florida.
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Journal ArticleDOI
First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas.
Jonathan R. Strosberg,Robert L. Fine,Junsung Choi,Aejaz Nasir,Domenico Coppola,Dung Tsa Chen,James F. Helm,Larry K. Kvols +7 more
TL;DR: In vitro data indicate that the combination of capecitabine and temozolomide is synergistic for induction of apoptosis in neuroendocrine tumor cell lines.
Journal ArticleDOI
Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non–Small Cell Lung Cancer, and Other Solid Tumors
Amita Patnaik,Lee S. Rosen,Sara M. Tolaney,Anthony W. Tolcher,Jonathan W. Goldman,Leena Gandhi,Kyriakos P. Papadopoulos,Muralidhar Beeram,Drew W. Rasco,John Hilton,Aejaz Nasir,Richard P. Beckmann,Andrew E. Schade,Angie D. Fulford,Tuan S. Nguyen,Ricardo Martinez,Palaniappan Kulanthaivel,Lily Q. Li,Martin Frenzel,Damien M. Cronier,Edward M. Chan,Keith T. Flaherty,Patrick Y. Wen,Geoffrey I. Shapiro +23 more
TL;DR: Abemaciclib represents the first selective inhibitor of CDK4 and CDK6 with a safety profile allowing continuous dosing to achieve sustained target inhibition, and this first-in-human experience demonstrates single-agent activity for patients with advanced breast cancer, NSCLC, and other solid tumors.
Journal ArticleDOI
Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue
Dung-Tsa Chen,Aejaz Nasir,Aedín C. Culhane,Chinnambally Venkataramu,William J. Fulp,Renee Rubio,Tao Wang,Deepak Agrawal,Susan McCarthy,Mike Gruidl,Gregory C. Bloom,Tove Anderson,Joseph White,John Quackenbush,Timothy J. Yeatman +14 more
TL;DR: The discovery of a “malignancy-risk” gene signature that may portend risk of breast cancer development in benign, but molecularly-abnormal, breast tissue is reported.
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Epithelial Progeny of Estrogen-Exposed Breast Progenitor Cells Display a Cancer-like Methylome
Alfred S. L. Cheng,Aedín C. Culhane,Michael W.Y. Chan,Michael W.Y. Chan,Chinnambally Venkataramu,Mathias Ehrich,Aejaz Nasir,Benjamin Rodriguez,Joseph Liu,Pearlly S. Yan,John Quackenbush,Kenneth P. Nephew,Timothy J. Yeatman,Tim H M Huang +13 more
TL;DR: The high prevalence of estrogen-induced epigenetic changes in primary tumors and the surrounding histologically normal tissues provides the first empirical link between estrogen injury of breast stem/progenitor cells and carcinogenesis.
Journal ArticleDOI
Correlation between grade and prognosis in metastatic gastroenteropancreatic neuroendocrine tumors.
TL;DR: It is concluded that a 3-tiered grading classification for gastroenteropancreatic neuroendocrine tumors correlates with survival in the metastatic setting and both mitotic rates and Ki-67 indexes are inversely associated with survival and can be analyzed independently for assignment of grade.