Showing papers by "Domenico Cozzetto published in 2008"
TL;DR: The worldwide Critical Assessment of techniques for protein Structure Prediction (CASP) initiative is described and the specific problems of assessing the quality of a protein 3D model are focused on.
Abstract: Methods for protein structure prediction are flourishing and becoming widely available to both experimentalists and computational biologists. However, how good are they? What is their range of applicability and how can we know which method is better suited for the task at hand? These are the questions that this review tries to address, by describing the worldwide Critical Assessment of techniques for protein Structure Prediction (CASP) initiative and focusing on the specific problems of assessing the quality of a protein 3D model.
16 citations
TL;DR: This review describes some relevant issues in the field of structural bioinformatics, emphasizig both open basic questions and the progress being continuously achieved.
Abstract: Three dimensional protein structures are crucial for understanding biology at both molecular and system level. Despite the advances in experimental structural biology, the pace of sequence deposition into databanks considerably exceeds that of structure determination. Inevitably the functional annotation of genes and genomes requires the exploitation of bioinformatics methods for protein sequence comparison and structure prediction. Hence monitoring objectively the state of art of the field is of paramount importance, in order to make best use of computational protein models to address biological questions. This review describes some relevant issues in the field of structural bioinformatics, emphasizig both open basic questions and the progress being continuously achieved. It is reasonably expected that these bioinformatics methods will increasingly contribute to the biomedical, pharmaceutical and biotechnological research.
14 citations
TL;DR: The Critical Assessment of Techniques for Protein Structure Prediction (CASP) initiative as discussed by the authors has been used to assess the quality of a protein 3D model and assess the suitability of different methods for the task at hand.
Abstract: Methods for protein structure prediction are flourishing and becoming widely available to both experimentalists and computational biologists. But, how good are they? What is their range of applicability and how can we know which method is better suited for the task at hand? These are the questions that this chapter tries to address, by describing automatic evaluation methods as well as the world-wide Critical Assessment of Techniques for Protein Structure Prediction (CASP) initiative and focusing on the specific problems of assessing the quality of a protein 3D model.
12 citations