D
Domenico Spina
Researcher at King's College London
Publications - 142
Citations - 6776
Domenico Spina is an academic researcher from King's College London. The author has contributed to research in topics: Bronchial hyperresponsiveness & Asthma. The author has an hindex of 40, co-authored 142 publications receiving 6339 citations. Previous affiliations of Domenico Spina include King's College & University of Cambridge.
Papers
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Journal ArticleDOI
Experimental design and analysis and their reporting: new guidance for publication in BJP.
Michael J. Curtis,Richard A. Bond,Domenico Spina,Amrita Ahluwalia,Stephen P A Alexander,Mark A. Giembycz,Annette Gilchrist,Daniel Hoyer,Paul A. Insel,Angelo A. Izzo,Andrew J Lawrence,David J. MacEwan,Lawrence D. F. Moon,Susan Wonnacott,Arthur H. Weston,John C. McGrath +15 more
TL;DR: In this article, the authors present a series of linked editorials in the context of biomedical journal abstracts, including: http://onlinelibrary.wiley.com/doi/10.1111/bph.12954/abstract, http://Onlinelabel. wiley. com/doi /10.12956/ABstract, https://www.wired.org/content/index.cfm/
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PDE4 inhibitors: current status
TL;DR: A number of strategies are currently being pursued in attempts to improve clinical efficacy and reduce side effects, including delivery via the inhaled route, and/or development of non‐emetic PDE4 inhibitors and mixed PDE inhibitors.
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Phosphodiesterase inhibitors: Phosphodiesterase inhibitors
TL;DR: This review focuses on the development of PDE3 inhibitors for congestive heart failure, PDE4 inhibitors for inflammatory airways disease and most successfully, Pde5 inhibitors for erectile dysfunction.
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In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline.
TL;DR: The results clearly indicate that the bronchial hyperreactivity to airway spasmogens observed in asthma is exclusively an in vivo phenomenon not involving increasing sensitivity of bronchia smooth muscle.
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Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation
Simon C. Pitchford,Stefania Momi,Stefania Momi,Silvia Giannini,Silvia Giannini,Lucio Casali,Lucio Casali,Domenico Spina,Clive P. Page,Paolo Gresele,Paolo Gresele +10 more
TL;DR: In this article, the importance of platelet adhesion molecule expression on pulmonary eosinophil and lymphocyte recruitment and on leukocyte CD11b and very late antigen (VLA)-4 expression in mice was investigated.