D
Dominique Muller
Researcher at University of Geneva
Publications - 87
Citations - 12047
Dominique Muller is an academic researcher from University of Geneva. The author has contributed to research in topics: Long-term potentiation & Synaptic plasticity. The author has an hindex of 44, co-authored 86 publications receiving 11580 citations.
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Journal ArticleDOI
A simple method for organotypic cultures of nervous tissue
TL;DR: Hippocampal slices prepared from 2-23-day-old neonates were maintained in culture at the interface between air and a culture medium and yielded thin slices which remain 1-4 cell layers thick and are characterized by a well preserved organotypic organization.
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Regulatory Phosphorylation of AMPA-Type Glutamate Receptors by CaM-KII During Long-Term Potentiation
Andres Barria,Dominique Muller,Victor A. Derkach,Leslie C. Griffith,Thomas R. Soderling,Thomas R. Soderling +5 more
TL;DR: Induction of LTP increased the phosphorus-32 labeling of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-Rs), which mediate rapid excitatory synaptic transmission and provides a postsynaptic molecular mechanism for synaptic plasticity.
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LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TL;DR: In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.
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PSA–NCAM Is Required for Activity-Induced Synaptic Plasticity
Dominique Muller,Cheng Wang,Galina Skibo,Nicolas Toni,Harold Cremer,V. Calaora,Geneviève Rougon,Jozsef Zoltan Kiss +7 more
TL;DR: Results indicate that neuronal activity regulates the expression of PSA-NCAM at the synapse and that this expression is required for the induction of synaptic plasticity.
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Enhanced hippocampal long-term potentiation and learning by increased neuronal expression of tissue-type plasminogen activator in transgenic mice.
Rime Madani,Sophie Hulo,Nicolas Toni,Hala Madani,Thierry Steimer,Dominique Muller,Jean-Dominique Vassalli +6 more
TL;DR: It is shown that transgenic mice overexpressing tPA in post‐natal neurons have increased and prolonged hippocampal long‐term potentiation (LTP), and improved performance in spatial orientation learning tasks.