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Irina Nikonenko
Researcher at University of Geneva
Publications - 44
Citations - 5117
Irina Nikonenko is an academic researcher from University of Geneva. The author has contributed to research in topics: Synaptic plasticity & Dendritic spine. The author has an hindex of 30, co-authored 43 publications receiving 4676 citations. Previous affiliations of Irina Nikonenko include Geneva College & University of Lausanne.
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LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite
TL;DR: In this paper, the morphology of synapses activated by high-frequency stimulation and identified by accumulated calcium in dendritic spines was analyzed using electron microscopy to identify the formation of new synapses contacting the same presynaptic terminal.
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Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learning
Matthew Brown,Kelly R. Tan,Eoin C. O'Connor,Irina Nikonenko,Dominique Muller,Christian Lüscher,Christian Lüscher +6 more
TL;DR: It is shown that GABA-releasing neurons of the VTA that project to the NAc (VTA GABA projection neurons) inhibit accumbal cholinergic interneurons (CINs) to enhance stimulus–outcome learning.
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Activity-Dependent Structural Plasticity of Perisynaptic Astrocytic Domains Promotes Excitatory Synapse Stability
Yann Bernardinelli,Jerome Randall,Elia Janett,Irina Nikonenko,Stéphane König,Emma V. Jones,Carmen E. Flores,Keith K. Murai,Christian G. Bochet,Anthony Holtmaat,Dominique Muller +10 more
TL;DR: This study identifies a novel bidirectional interaction between synapses and astrocytes, in which synaptic activity and synaptic potentiation regulate PAP structural plasticity, which in turn determines the fate of the synapse.
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Polysialylated Neural Cell Adhesion Molecule Promotes Remodeling and Formation of Hippocampal Synapses
Alexander Dityatev,Galina Dityateva,Vladimir Sytnyk,Markus Delling,Nicolas Toni,Irina Nikonenko,Dominique Muller,Melitta Schachner +7 more
TL;DR: It is shown that enzymatic removal of PSA with endoneuraminidase-N (endo-N) abolished preferential formation of synapses on NCAM-expressing cells in heterogenotypic cocultures of wild-type andNCAM-deficient hippocampal neurons, and interaction of NCAM with heparan sulfate proteoglycans mediates this activity.
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Remodeling of Synaptic Membranes after Induction of Long-Term Potentiation
Nicolas Toni,Pierre-Alain Buchs,Irina Nikonenko,Patrisia Povilaitite,Lorena Parisi,Dominique Muller +5 more
TL;DR: The idea that LTP induction is associated with an enhanced recycling of synaptic membrane and that this process could underlie the formation of synapses with segmented PSDs and eventually result in theformation of a new, immature spine is supported.