D
Donald G. Moerman
Researcher at University of British Columbia
Publications - 115
Citations - 9109
Donald G. Moerman is an academic researcher from University of British Columbia. The author has contributed to research in topics: Caenorhabditis elegans & Gene. The author has an hindex of 48, co-authored 113 publications receiving 8449 citations. Previous affiliations of Donald G. Moerman include University of Calgary & Washington University in St. Louis.
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Journal ArticleDOI
High-Throughput In Vivo Analysis of Gene Expression in Caenorhabditis elegans
Rebecca Hunt-Newbury,Ryan Viveiros,Robert C. Johnsen,Allan K. Mah,Dina Anastas,Lily Li Fang,Erin Halfnight,David Lee,John Lin,Adam Lorch,Sheldon J. McKay,H. Mark Okada,Jie Pan,Ana K Schulz,Domena Tu,Kim Wong,Zhongying Zhao,Andrey Alexeyenko,Thomas R. Bürglin,Eric Sonnhammer,Ralf Schnabel,Steven J.M. Jones,Marco A. Marra,David L. Baillie,Donald G. Moerman +24 more
TL;DR: Using DNA sequences 5′ to open reading frames, green fluorescent protein (GFP) fusions are constructed and generated spatial and temporal tissue expression profiles for 1,886 specific genes in the nematode Caenorhabditis elegans.
Journal ArticleDOI
The Million Mutation Project: A new approach to genetics in Caenorhabditis elegans
Owen Thompson,Mark L. Edgley,Pnina Strasbourger,Stephane Flibotte,Brent Ewing,Ryan Adair,Vinci Au,Iasha Chaudhry,Lisa Fernando,Harald Hutter,Armelle Kieffer,Joanne Lau,Norris Lee,Angela Miller,Greta Raymant,Bin Shen,Jay Shendure,Jon Taylor,Emily H. Turner,LaDeana W. Hillier,Donald G. Moerman,Robert H. Waterston +21 more
TL;DR: A nonsense suppressor is revealed as well as strains with higher levels of indels that harbor mutations in DNA repair genes and strains with abundant males associated with him mutations, providing an unprecedented genetic resource for this multicellular organism.
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Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans.
Guy M. Benian,Jane E. Kiff,Jane E. Kiff,Nicolas Neckelmann,Donald G. Moerman,Donald G. Moerman,Robert H. Waterston +6 more
TL;DR: Homologies of the sequence of twit-chin have unexpected similarities to the sequences of proteins of the immunoglobulin superfamily, cell adhesion molecules and vertebrate muscle proteins, including myosin light-chain kinase, which indicate that the protein is involved in a novel mechanism of myOSin regulation.
Journal ArticleDOI
C. elegans PAT-4/ILK Functions as an Adaptor Protein within Integrin Adhesion Complexes
TL;DR: The data strengthens the emerging view that ILK functions primarily as an adaptor protein within integrin adhesion complexes and identifies UNC-112 as a new ILK binding partner.
Journal ArticleDOI
Gene expression profiling of cells, tissues, and developmental stages of the nematode C. elegans.
Sheldon J. McKay,Robert C. Johnsen,Jaswinder Khattra,Jennifer Asano,David L. Baillie,Susanna Y. Chan,N. Dube,L. Fang,Barbara Goszczynski,E. Ha,E. Halfnight,R. Hollebakken,P. Huang,Kineta Hung,Victor L. Jensen,Steven J.M. Jones,H. Kai,Dion Tik Shun Li,A. Mah,Marco A. Marra,James D. McGhee,R. Newbury,Anatoli Timofeyevich Pouzyrev,Donald L. Riddle,Erik L. L. Sonnhammer,H. Tian,D. Tu,John R. Tyson,G. P. Vatcher,Adam Warner,Kim Wong,Zhongying Zhao,Donald G. Moerman +32 more
TL;DR: The ultimate goal is not only to describe detailed gene expression profiles, but also to gain a greater understanding of the organization of gene regulatory networks and to determine how they control cell function during development and differentiation in C. elegans.