P
Pnina Strasbourger
Researcher at University of Washington
Publications - 5
Citations - 871
Pnina Strasbourger is an academic researcher from University of Washington. The author has contributed to research in topics: Mutant & Caenorhabditis elegans. The author has an hindex of 4, co-authored 5 publications receiving 756 citations.
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Journal ArticleDOI
The Million Mutation Project: A new approach to genetics in Caenorhabditis elegans
Owen Thompson,Mark L. Edgley,Pnina Strasbourger,Stephane Flibotte,Brent Ewing,Ryan Adair,Vinci Au,Iasha Chaudhry,Lisa Fernando,Harald Hutter,Armelle Kieffer,Joanne Lau,Norris Lee,Angela Miller,Greta Raymant,Bin Shen,Jay Shendure,Jon Taylor,Emily H. Turner,LaDeana W. Hillier,Donald G. Moerman,Robert H. Waterston +21 more
TL;DR: A nonsense suppressor is revealed as well as strains with higher levels of indels that harbor mutations in DNA repair genes and strains with abundant males associated with him mutations, providing an unprecedented genetic resource for this multicellular organism.
Journal ArticleDOI
Comparative analysis of the transcriptome across distant species
Mark Gerstein,Joel Rozowsky,Koon-Kiu Yan,Daifeng Wang,Chao Cheng,James B. Brown,James B. Brown,Carrie A. Davis,LaDeana W. Hillier,Cristina Sisu,Jingyi Jessica Li,Jingyi Jessica Li,Baikang Pei,Arif Harmanci,Michael O. Duff,Sarah Djebali,Roger P. Alexander,Burak H. Alver,Raymond K. Auerbach,Kimberly Bell,Peter J. Bickel,Max E. Boeck,Nathan Boley,Nathan Boley,Benjamin W. Booth,Lucy Cherbas,Peter Cherbas,Chao Di,Alexander Dobin,Jorg Drenkow,Brent Ewing,Gang Fang,Megan Fastuca,Elise A. Feingold,Adam Frankish,Guanjun Gao,Peter J. Good,Roderic Guigó,Ann S. Hammonds,Jen Harrow,Roger A. Hoskins,Cédric Howald,Cédric Howald,Long Hu,Haiyan Huang,Tim Hubbard,Tim Hubbard,Chau Huynh,Sonali Jha,Dionna M. Kasper,Masaomi Kato,Thomas C. Kaufman,Robert R. Kitchen,Erik Ladewig,Julien Lagarde,Eric C. Lai,Jing Leng,Zhi Lu,Michael J. MacCoss,Gemma E. May,Gemma E. May,Rebecca McWhirter,Gennifer E. Merrihew,David M. Miller,Ali Mortazavi,Rabi Murad,Brian Oliver,Sara Olson,Peter J. Park,Michael J. Pazin,Norbert Perrimon,Norbert Perrimon,Dmitri D. Pervouchine,Valerie Reinke,Alexandre Reymond,Garrett Robinson,Anastasia Samsonova,Anastasia Samsonova,Gary Saunders,Gary Saunders,Felix Schlesinger,Anurag Sethi,Frank J. Slack,William C. Spencer,Marcus H. Stoiber,Marcus H. Stoiber,Pnina Strasbourger,Andrea Tanzer,Andrea Tanzer,Owen Thompson,Kenneth H. Wan,Guilin Wang,Huaien Wang,Kathie L. Watkins,Jiayu Wen,Kejia Wen,Chenghai Xue,Li Yang,Li Yang,Kevin Y. Yip,Chris Zaleski,Yan Zhang,Henry Zheng,Steven E. Brenner,Brenton R. Graveley,Susan E. Celniker,Thomas R. Gingeras,Robert H. Waterston +107 more
TL;DR: It is found in all three organisms that the gene-expression levels, both coding and non-coding, can be quantitatively predicted from chromatin features at the promoter using a ‘universal model’ based on a single set of organism-independent parameters.
Journal ArticleDOI
Polymyxin Resistance of Pseudomonas aeruginosa phoQ Mutants Is Dependent on Additional Two-Component Regulatory Systems
Alina D. Gutu,Nicole Sgambati,Pnina Strasbourger,Mark K. Brannon,Michael A. Jacobs,Eric Haugen,Rajinder Kaul,Helle Krogh Johansen,Niels Høiby,Samuel M. Moskowitz,Samuel M. Moskowitz +10 more
TL;DR: ColRS and CprRS are defined as two-component systems regulating polymyxin resistance in P. aeruginosa, indicate that addition of 4-amino-l-arabinose to lipid A is not the only PhoPQ-regulated biochemical mechanism required for resistance, and demonstrate that colRS and cprS mutations can contribute to high-level clinical resistance.
Journal ArticleDOI
Isolation of specific neurons from C. elegans larvae for gene expression profiling.
W. Clay Spencer,Rebecca McWhirter,Tyne Miller,Pnina Strasbourger,Owen Thompson,LaDeana W. Hillier,Robert H. Waterston,David M. Miller +7 more
TL;DR: A simple and robust protocol for expression profiling studies of post-embryonic C. elegans neurons and thus provides an important new method for identifying candidate genes for key roles in neuron-specific development and function.