D
Donald Smith
Researcher at Tufts University
Publications - 117
Citations - 5187
Donald Smith is an academic researcher from Tufts University. The author has contributed to research in topics: Vitamin & Vitamin E. The author has an hindex of 37, co-authored 117 publications receiving 4861 citations. Previous affiliations of Donald Smith include United States Department of Veterans Affairs & United States Department of Agriculture.
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Journal ArticleDOI
Retinoid Signaling and Activator Protein-1 Expression in Ferrets Given β-Carotene Supplements and Exposed to Tobacco Smoke
Xiang-Dong Wang,Chun Liu,Roderick T. Bronson,Donald Smith,Norman I. Krinsky,Robert M. Russell +5 more
TL;DR: Diminished retinoid signaling, resulting from the suppression of RARbeta gene expression and overexpression of activator protein-1, could be a mechanism to enhance lung tumorigenesis after high-dose beta-carotene supplementation and exposure to tobacco smoke.
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Folate-deficiency-induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism.
TL;DR: Plasma homocysteine and hepatic AdoMet concentrations were inversely correlated as folate status was modified, and the effect of ethionine is thought to be exerted through S-adenosylethionine, which is formed in the liver of these rats.
Journal Article
Folate Deficiency Enhances the Development of Colonic Neoplasia in Dimethylhydrazine-treated Rats
Marília Cravo,Joel B. Mason,Yogeshwar Dayal,Martha Hutchinson,Donald Smith,Jacob Selhub,Irwin H. Rosenberg +6 more
TL;DR: Folate deficiency increases the risk of malignancy when there is an underlying predisposition to colorectal cancer, in this animal model.
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Dietary Conjugated Linoleic Acid Influences the Immune Response of Young and Old C57BL/6NCrlBR Mice.
Michael G. Hayek,Sung Nim Han,Dayong Wu,Bruce A. Watkins,Mohsen Meydani,Jodee L. Dorsey,Donald Smith,Simin Nikbin Meydani +7 more
TL;DR: CLA supplementation significantly increased all CLA isomers measured in hepatic neutral lipids and phospholipids and had no effect on NK cell activity, PGE2 production or DTH in young or old mice.
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Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats.
TL;DR: The plasma homocysteine response to methionine loading was assessed in vitamin B-6- and folate-deficient rats and results have significant bearing on the interpretation of both positive and negative responses to methIONine loading in humans.