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Dongyu Zhang
Researcher at University of Florida Health Science Center
Publications - 5
Citations - 99
Dongyu Zhang is an academic researcher from University of Florida Health Science Center. The author has contributed to research in topics: Tumor microenvironment & Metastasis. The author has an hindex of 4, co-authored 5 publications receiving 73 citations. Previous affiliations of Dongyu Zhang include University of Florida.
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Journal ArticleDOI
Primary outgrowth cultures are a reliable source of human pancreatic stellate cells.
Song Han,Daniel Delitto,Dongyu Zhang,Heather L. Sorenson,George A. Sarosi,George A. Sarosi,Ryan M. Thomas,Ryan M. Thomas,Kevin E. Behrns,Shannon M. Wallet,Jose G. Trevino,Steven J. Hughes +11 more
TL;DR: Primary cultures from pancreatic surgical specimens, including malignancies, may represent a reliable source of human PSCs that demonstrate consistent growth and protein secretion properties, regardless of donor pathology.
Journal ArticleDOI
Nicotine Reduces Survival via Augmentation of Paracrine HGF–MET Signaling in the Pancreatic Cancer Microenvironment
Daniel Delitto,Dongyu Zhang,Song Han,Brian S. Black,Andrea E. Knowlton,Adrian C. Vlada,George A. Sarosi,Kevin E. Behrns,Ryan M. Thomas,Xiaomin Lu,Chen Liu,Thomas J. George,Steven J. Hughes,Shannon M. Wallet,Jose G. Trevino +14 more
TL;DR: A novel, microenvironment-dependent paracrine signaling mechanism by which nicotine exposure promotes the growth and metastasis of pancreatic cancer is demonstrated.
Journal ArticleDOI
The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma
Song Han,David Hernandez Gonzalo,Michael Feely,Daniel Delitto,Kevin E. Behrns,Mark Beveridge,Dongyu Zhang,Ryan M. Thomas,Jose G. Trevino,Thomas D. Schmittgen,Steven J. Hughes +10 more
TL;DR: Data suggest interactions within the tumor microenvironment alter miRNA expression, which in turn have a functional impact on TAS, as well as regulation of mi RNA expression by cell-cell contact.
Journal ArticleDOI
Nicotine Induces IL-8 Secretion from Pancreatic Cancer Stroma and Worsens Cancer-Induced Cachexia.
Patrick W. Underwood,Dongyu Zhang,Miles E. Cameron,Michael H. Gerber,Daniel Delitto,Michael U Maduka,Kyle J Cooper,Song Han,Steven J. Hughes,Sarah M. Judge,Andrew Judge,Jose G. Trevino +11 more
TL;DR: Nicotine treatment of mice bearing pancreatic cancer patient-derived xenografts had significantly increased tumor mass, increased tumor-free weight loss, and decreased muscle mass, which represent important pathways through which nicotine acts within the tumor microenvironment and worsens pancreatIC cancer-induced cachexia, potentially representing future therapeutic targets.
Journal ArticleDOI
Selective Disruption of Rb–Raf-1 Kinase Interaction Inhibits Pancreatic Adenocarcinoma Growth Irrespective of Gemcitabine Sensitivity
Jose G. Trevino,Monika Verma,Sandeep Singh,Smitha Pillai,Dongyu Zhang,Daniele Pernazza,Said M. Sebti,Nicholas J. Lawrence,Barbara A. Centeno,Srikumar Chellappan +9 more
TL;DR: D-251 significantly reduced tumor growth in vivo accompanied by reduced Rb phosphorylation and lymph node and liver metastasis and combination with gemcitabine showed cooperative effect on tumor growth (P < 0.01).