J
Jose G. Trevino
Researcher at University of Florida
Publications - 125
Citations - 4140
Jose G. Trevino is an academic researcher from University of Florida. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 32, co-authored 122 publications receiving 3225 citations. Previous affiliations of Jose G. Trevino include University of Florida Health & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
A randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage
George Van Buren,Mark Bloomston,Steven J. Hughes,Jordan M. Winter,Stephen W. Behrman,Nicholas J. Zyromski,Charles M. Vollmer,Vic Velanovich,Taylor S. Riall,Peter Muscarella,Jose G. Trevino,Attila Nakeeb,C. Max Schmidt,Kevin E. Behrns,E. Christopher Ellison,Omar Barakat,Kyle A. Perry,Jeffrey A. Drebin,Michael G. House,Sherif Abdel-Misih,Eric J. Silberfein,Steven B. Goldin,Kimberly M. Brown,Somala Mohammed,Sally E. Hodges,Amy L. McElhany,Mehdi A. Issazadeh,Eunji Jo,Qianxing Mo,William E. Fisher +29 more
TL;DR: This study provides level 1 data, suggesting that elimination of intraperitoneal drainage in all cases of PD increases the frequency and severity of complications.
Journal ArticleDOI
EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer
Sandeep Singh,Jose G. Trevino,Namrata Bora-Singhal,Domenico Coppola,Eric B. Haura,Soner Altiok,Srikumar Chellappan +6 more
TL;DR: It is shown that abrogation of EGFR, Src and Akt signaling through pharmacological or genetic inhibitors suppresses the self-renewal growth and expansion of SP-cells and resulted in specific downregulation of Sox2 protein expression, suggesting that Sox2 is a novel target of EGfr-Src-Akt signaling in NSCLCs that modulates self-Renewal and expansion in stem-like cells from NSCLC.
Journal ArticleDOI
Inhibition of Src expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model
Jose G. Trevino,Justin M. Summy,Donald P. Lesslie,Nila U. Parikh,David S. Hong,Francis Y. Lee,Nicholas J. Donato,James L. Abbruzzese,Cheryl H. Baker,Gary E. Gallick +9 more
TL;DR: It is demonstrated that Src activation contributes to pancreatic tumor progression in this model, offering Src as a candidate for targeted therapy.
Journal ArticleDOI
Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism.
Monique B. Nilsson,Guillermo N. Armaiz-Pena,Rie Takahashi,Yvonne G. Lin,Jose G. Trevino,Yang Li,Nicholas B. Jennings,Jesusa M.G. Arevalo,Susan K. Lutgendorf,Gary E. Gallick,Angela Sanguino,Gabriel Lopez-Berestein,Steven W. Cole,Anil K. Sood +13 more
TL;DR: It is shown that stress hormones such as norepinephrine lead to increased expression of IL-6 mRNA and protein levels in ovarian carcinoma cells and that norpinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL- 6 expression.
Journal ArticleDOI
Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases.
Donald P. Lesslie,Justin M. Summy,Nila U. Parikh,Fan Fan,Jose G. Trevino,Tomi K. Sawyer,Chester A. Metcalf,William C. Shakespeare,Daniel J. Hicklin,Lee M. Ellis,Gary E. Gallick +10 more
TL;DR: Investigating the role of Src family kinases (SFKs) in VEGF-mediated signalling in human colorectal carcinoma (CRC) cell lines suggests that VEGFR-1 promotes migration of tumour cells through a Src-dependent pathway linked to activation of focal adhesion components that regulate this process.