D
Donna Collins-McMillen
Researcher at University of Arizona
Publications - 17
Citations - 651
Donna Collins-McMillen is an academic researcher from University of Arizona. The author has contributed to research in topics: Human cytomegalovirus & Population. The author has an hindex of 13, co-authored 17 publications receiving 511 citations. Previous affiliations of Donna Collins-McMillen include LSU Health Sciences Center Shreveport.
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Journal ArticleDOI
Molecular Determinants and the Regulation of Human Cytomegalovirus Latency and Reactivation
TL;DR: The complex persistence of HCMV is reviewed with consideration of latent reservoirs, viral determinants and their host interactions, and host signaling and the control of cellular and viral gene expression that contributes to the establishment of and reactivation from latency.
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The HCMV gH/gL/UL128-131 Complex Triggers the Specific Cellular Activation Required for Efficient Viral Internalization into Target Monocytes
Maciej T. Nogalski,Gary C. T. Chan,Emily V. Stevenson,Donna Collins-McMillen,Andrew D. Yurochko +4 more
TL;DR: It is demonstrated that the presence of the gH/gL/UL128-131 complex on the viral envelope, through its activation of the integrin/Src/paxillin pathway, is necessary for efficient HCMV internalization into monocytes and that appropriate actin and dynamin regulation is critical for this entry process.
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Human Cytomegalovirus Requires Epidermal Growth Factor Receptor Signaling To Enter and Initiate the Early Steps in the Establishment of Latency in CD34+ Human Progenitor Cells
TL;DR: HCMV activation of the epidermal growth factor receptor (EGFR) and downstream phosphatidylinositol 3-kinase (PI3K) mediates viral entry into CD34+ human progenitor cells (HPCs), resulting in distinct cellular trafficking and nuclear translocation of the virus compared to that in other immune cells.
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HCMV reprogramming of infected monocyte survival and differentiation: a Goldilocks phenomenon.
Emily V. Stevenson,Donna Collins-McMillen,Jung Heon Kim,Stephen J. Cieply,Gretchen L. Bentz,Andrew D. Yurochko +5 more
TL;DR: The induction of a uniquely polarized macrophage subset from infected monocytes is described, which is argued to be the ideal cellular environment for the initiation of viral gene expression and replication and, ultimately, viral spread and persistence within the infected host.
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Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome
TL;DR: It is proposed that herpesviruses evolved a multipartite entry system to allow interaction with multiple receptors, including integrins, required for their sophisticated life cycle.