Showing papers by "Donna G. Blackmond published in 1998"
TL;DR: In this paper, reaction simulations based on parameters derived from initial enantioselectivity data provide an extension of the Kagan MLn models as powerful mechanistic tools in asymmetric synthesis.
Abstract: Observation of a conversion-dependent enantioselectivity in asymmetric reactions with nonenantiopure catalysts or reagents may be diagnostic of kinetically complex behavior. This paper shows how reaction simulations based on parameters derived from initial enantioselectivity data provide an extension of the Kagan MLn models as powerful mechanistic tools in asymmetric synthesis. This approach is illustrated for an example of a stoichiometric reduction of aralkyl ketones with chiral borane reagents and is also discussed for several cases of catalytic reactions.
33 citations
TL;DR: In this article, a novel class of heterogeneous catalysts prepared from inorganic Grignard reagents is shown to provide finely divided transition metal-carbon nanostructures with potential advantages as selective hydrogenation catalysts under mild liquid phase conditions.
Abstract: A novel class of heterogeneous catalysts prepared from inorganic Grignard reagents is shown to provide finely divided transition metal–carbon nanostructures with potential advantages as selective hydrogenation catalysts under mild liquid‐phase conditions. Preliminary investigations of the catalytic behavior of these materials in diastereoselective reductive amination reactions are described.
19 citations
18 citations
TL;DR: Theoretical considerations and experimental results demonstrate that reaction calorimetry is a valid and accurate measure of the hydrogenation reaction, provided that the substrate and its hemiketal remain in equilibrium over the course of the reaction as discussed by the authors.
4 citations