Showing papers by "Donna G. Blackmond published in 2000"
TL;DR: It is demonstrated how consideration of the kinetic behavior may serve to enhance the use of nonlinear effects as a diagnostic tool for identifying active catalytic species and for providing mechanistic insight in the development of efficient synthetic strategies using non-enantiopure systems.
Abstract: Probing catalyst systems for a nonlinear relationship between product enantioselectivity and catalyst enantiopurity is now commonly being used as a mechanistic tool. We show that in some cases striking consequences for reaction rate can ensue for reactions carried out using non-enantiopure catalysts. We also demonstrate how consideration of the kinetic behavior may serve to enhance the use of nonlinear effects as a diagnostic tool for identifying active catalytic species and for providing mechanistic insight. Kinetic information may also help in the development of efficient synthetic strategies using non-enantiopure systems.
180 citations
TL;DR: Cationic iridium complexes with chiral phosphinooxazoline ligands are efficient catalysts for the enantioselective hydrogenation of olefins because they do not require the presence of a polar coordinating group near the C=C bond.
86 citations
TL;DR: In situ reaction rate measurements help to define the role of product inhibition in the asymmetric alkylation of benzaldehyde with diethylzinc using (-)-MIB as a chiral reagent.
54 citations
TL;DR: In this paper, the authors show that in some cases striking consequences for reaction rate can ensue for reactions carried out using non-enantiopure catalysts, and they also demonstrate how consideration of the kinetic behavior may serve to enhance the use of nonlinear effects as a diagnostic tool for identifying active catalytic species and for providing mechanistic insight.
Abstract: Probing catalyst systems for a nonlinear relationship between product enantioselectivity and catalyst enantiopurity is now commonly being used as a mechanistic tool. We show that in some cases striking consequences for reaction rate can ensue for reactions carried out using non-enantiopure catalysts. We also demonstrate how consideration of the kinetic behavior may serve to enhance the use of nonlinear effects as a diagnostic tool for identifying active catalytic species and for providing mechanistic insight. Kinetic information may also help in the development of efficient synthetic strategies using non-enantiopure systems.
1 citations