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Donna J. Koerker
Researcher at University of Washington
Publications - 32
Citations - 2115
Donna J. Koerker is an academic researcher from University of Washington. The author has contributed to research in topics: Somatostatin & Glucagon. The author has an hindex of 21, co-authored 32 publications receiving 2089 citations.
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Journal ArticleDOI
Somatostatin: Hypothalamic Inhibitor of the Endocrine Pancreas
Donna J. Koerker,Willy Ruch,Elliott W. Chideckel,Jerry P. Palmer,Charles J. Goodner,John W. Ensinck,Charles C. Gale +6 more
TL;DR: Somatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion infasted cats and rats and in fasted baboons both basal and arginine- stimulated secretion of insulin and glucagon are inhibited.
Journal ArticleDOI
Insulin, glucagon, and glucose exhibit synchronous, sustained oscillations in fasting monkeys
Charles J. Goodner,Barbara C. Walike,Donna J. Koerker,John W. Ensinck,Arthur C. Brown,Elliott W. Chideckel,Jerry P. Palmer,Lynne W. Kalnasy +7 more
TL;DR: In overnight fasted rhesus monkeys, synchronous, regular oscillations occurred in the plasma concentrations of glucose, insulin, and glucagon, and in baboons, oscillations of glucose and insulin were smaller than in rhesUS monkeys, while in man,regular oscillations were not observed.
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Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons.
David A. D'Alessio,Robin E. Vogel,Ron L. Prigeon,Ellen C. Laschansky,Donna J. Koerker,John Eng,John W. Ensinck +6 more
TL;DR: Elimination of the action of GLP-1 impaired the disposition of an intragastric glucose meal and this was at least partly attributable to diminished early insulin release, demonstrating the important role of GLp-1 in the assimilation of glucose absorbed from the gut.
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Correlations of In Vivo β-Cell Function Tests With β-Cell Mass and Pancreatic Insulin Content in Streptozocin-Administered Baboons
TL;DR: Physiological measures of β-cell function were significantly correlated with both PIC andβ-cell mass, and such physiological measurements give an accurate valid reflection of changes in β- cell mass and pancreatic insulin content.
Journal ArticleDOI
Somatostatin blockade of acute and chronic stimuli of the endocrine pancreas and the consequences of this blockade on glucose homeostasis.
E W Chideckel,Jerry P. Palmer,Donna J. Koerker,John W. Ensinck,M B Davidson,Charles J. Goodner +5 more
TL;DR: Present evidence suggests that the effect of somatostatin on blood glucose is mediated through its effect on blood glucagon, and in the overnight-fasted baboon both in the basal state and 45 min into a 4-mg/kg-min glucose infusion, a som atostatin-induced fall in serum insulin levels appears to be unable to prevent a decrease in hepatic glucose production.