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Donna K. Pauler
Researcher at Fred Hutchinson Cancer Research Center
Publications - 20
Citations - 3570
Donna K. Pauler is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Population & Bayes factor. The author has an hindex of 13, co-authored 20 publications receiving 3401 citations. Previous affiliations of Donna K. Pauler include Harvard University.
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Journal ArticleDOI
Prevalence of Prostate Cancer among Men with a Prostate-Specific Antigen Level ≤4.0 ng per Milliliter
Ian M. Thompson,Donna K. Pauler,Phyllis J. Goodman,Catherine M. Tangen,M. Scott Lucia,Howard L. Parnes,Lori M. Minasian,Leslie G. Ford,Scott M. Lippman,E. David Crawford,John Crowley,Charles A. Coltman +11 more
TL;DR: Biopsy-detected prostate cancer, including high-grade cancers, is not rare among men with PSA levels of 4.0 ng per milliliter or less--levels generally thought to be in the normal range.
Journal ArticleDOI
Screening based on the risk of cancer calculation from Bayesian hierarchical changepoint and mixture models of longitudinal markers
TL;DR: Simulations of a prospective trial using a strategy based on the risk calculated from longitudinal CA125 values indicate potentially large increases in sensitivity for a given specificity compared to the standard approach based on a fixed CA125 reference level for all subjects.
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The Schwarz criterion and related methods for normal linear models
TL;DR: In this paper, the authors derive Schwarz's information criterion and two modifications for choosing fixed effects in normal linear mixed models, and apply their results to evaluate a large class of models for repeated neuron area measurements in alcoholic and suicidal patients.
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Primary medical therapy of micro- and macroprolactinomas in men.
Joseph J. Pinzone,Laurence Katznelson,Daniel C. Danila,Donna K. Pauler,Caleb S. Miller,Anne Klibanski +5 more
TL;DR: It is found that normalization of serum PRL levels occurs in approximately 80% of men with prolactinomas, and dopamine agonist administration yielded similar biochemical remission rates in men with microprolactinoma and macroprolACTinomas.
Journal Article
Factors Influencing Serum CA125II Levels in Healthy Postmenopausal Women
Donna K. Pauler,Usha Menon,Martin W. McIntosh,Heather L. Symecko,Steven J. Skates,Ian Jacobs +5 more
TL;DR: It is concluded that clinically significant differences in individual patient characteristics need to be reflected in the screening algorithms that use CA125II so that designed performance characteristics (sensitivity and specificity) are maintained in practice.