Donovan D Trinidad

TL;DR: The results indicate that nutrient absorption is sensitive to environmental perturbations and support the translational relevance of preclinical models demonstrating a possible causal role for the gut microbiome in dietary energy harvest.

TL;DR: Cryo-electron microscopy structure of an ESX-3 system, purified using an epitope tag inserted with recombineering into the chromosome of the model organism Mycobacterium smegmatis, reveals a stacked architecture that extends above and below the inner membrane of the bacterium.

TL;DR: In this article , a low cost and bias method, DIMPLE, was developed for systematically generating deletions, insertions, and missense mutations in genes, which were test on a range of targets, including Kir2.1.

TL;DR: In this article , a structure-function model of OCT1s conformational ensemble without experimental structures is presented, showing that the major determinants of folding reside in the first 300 amino acids, including the first 6 transmembrane domains and the extracellular domain with a stabilizing and highly conserved stabilizing helical motif.